龙血素B在模拟失重大鼠体内的血浆药物动力学研究  

Research on Pharmacokinetics of Loureirin B in Plasma of Rats under Simulated Weightlessness

作　　者：李玉娟[1] 张宇实[1,2] 陈博[1] 甘琳[1] 邓力[1] 邓玉林[1] 

机构地区：[1]北京理工大学生命学院,北京100081 [2]中国中医科学院中药研究所,北京100029

出　　处：《航天医学与医学工程》2014年第2期79-83,共5页Space Medicine & Medical Engineering

基　　金：国家重大仪器专项(2012YQ040140);国家自然科学基金资助项目(81202996)

摘　　要：目的研究模拟失重大鼠灌胃龙血竭后有效成分龙血素B的血浆药物动力学。方法采用3周尾吊大鼠模型模拟失重状态,单次灌胃给予10.6 g/kg龙血竭后,收集各个时间点血浆样本,HPLC-MS/MS法测定尾吊大鼠血浆中龙血素B的含量,并求算药物动力学参数。结果龙血素B在模拟失重大鼠体内血药浓度-时间曲线下面积(AUC0-T)为(23.4±12.4)μg/L·h,达峰时间(Tmax)为(0.33±0.11)h,达峰浓度Cmax(2.77±0.71)μg/L,表观分布容积(Vc)为(677.6±111.6)L/kg。生物半衰期(T0.5)为(8.47±1.7)h。结论本文首次报道了龙血素B在模拟失重大鼠体内的药物动力学参数,为龙血竭对抗空间疾病的相关研究提供了药动学数据。Objective To investigate pharmacokinetics of loureirin B in the plasma of rats under simulated weightlessness after oral administration of Dragon＇ s Blood. Methods Rats were tail suspended for three weeks to simulate weightlessness. After the rats were orally administered with single dose of 10.6 g/kg Dragon＇ s Blood, plasma samples were collected and loureirin B was quantified by HPLC-MS/MS method. Pharmacoki- netic parameters were estimated. Results The area under curves （AUC 0-T）, time to peak concentration （Tmax ）, maximum concentration （Cmax ）, volume of distribution （Vc） and biological half-life （T0.5 ） were （23.4 ± 12.4）μg/L · h,（0.33 ±0.11）h,（2.77 ±0.71）μg/L, （677.6 ± lll.6）L/kg, （8.47±1.7）h, respectively. Conclusion The present study firstly reports pharmacokinetic parameters of loureirin B in simula- ted weightless rats, which may provide a pharmacokinetic basis for protective effect of Dragon＇ s blood on space disease.

关 键 词：模拟失重 龙血竭 龙血素B 药物动力学 

分 类 号：R859[医药卫生—航空、航天与航海医学]