电针刺激对人体4d头低位卧床心血管调节功能的影响  

Effects of Electroacupuncture on Cardiovascular Regulatory Function Under 4 Day Head-down Bed Rest

作　　者：孙静[1] 李小涛[1] 杨长斌[1] 石菲[1] 王永春[1] 赵疆东[1] 孙喜庆[1] 

机构地区：[1]第四军医大学航空航天医学系,航空航天医学教育部重点实验室,陕西西安710032

出　　处：《航天医学与医学工程》2014年第2期146-148,共3页Space Medicine & Medical Engineering

基　　金：国家自然科学基金资助项目(81301682);军队青年培育项目(13QNP123)

摘　　要：目的探讨电针刺激内关穴对抗模拟失重所致心血管功能失调的防护作用。方法 14名健康男性志愿者随机分为对照组和电针组。对照组仅进行4 d头低位卧床,电针组则在卧床期间给予双侧"内关穴"电针刺激,30 min/d,连续4 d。卧床前后进行立位耐力、心脏功能、心率变异性以及血液血管紧张素II及醛固酮浓度测定。结果与卧床前相比,对照组卧床后立位耐力、心脏收缩功能及低频与高频功率的比值(LF/HF)均显著降低(P<0.05)。电针组卧床后LF/HF以及血液血管紧张素和醛固酮浓度显著增高(P<0.05),立位耐力呈下降趋势,未达到显著水平(P>0.05),卧床前后心脏功能无明显变化(P>0.05)。结论 4 d头低位卧床可导致心脏功能降低,立位耐力下降。电针刺激"内关穴"可提高交感神经兴奋性,增加血液血管紧张素-醛固酮的释放,进而有效维持头低位卧床期间心脏功能以及立位耐力。Objective To investigate the protection effects of electroacupubcture （EA） stimulating Neiguan ca- ves on maladjustment of cardiovascular function under short-term simulated weightlessness. Methods Fourteen healthy volunteers performed 4 days of -6°head-down bed rest （HDBR） were randomly divided into control group C without any intervention and EA group received EA treatment on bilateral Neiguan cave （PC 6 ） 30 min/day for 4 days during HDBR. Orthostatic tolerance, cardiac systolic function, heart rate variability （HRV） and plasma cateeholamine（ angiotensin II and aldosterone） were measured pre- and post- HDBR. Results Compared with pre-HDBR, orthostatic tolerance and cardiac systolic function in control group de- creased significantly after HDBR （P 〈 0.05 ） , while these variables remained unchanged due to daily 30 min EA （P 〉 0.05 ）. In addition, heart rate variability analysis revealed that EA at PC 6 made high-frequency ranges of R-R interval decreased while increasing low-frequency ranges of R-R interval, which indicated an elevated heart sympathetic tone. Conclusion HDBR for 4 days can lead cardiac systolic function and orthostatic tolerance to a significant decrease. EA treatment at Neiguan caves was highly effective in activating peripheral sympathetic nervous system and activating renin-angiotensin-aldosterone system （RAAS）, which might be re- sponsible for improved orthostatic tolerance.

关 键 词：头低位卧床 电针 立位耐力 心率变异性 心功能 内关穴 

分 类 号：R856.2[医药卫生—航空、航天与航海医学] R852.22[医药卫生—临床医学]