骨髓间充质干细胞在肾衰竭治疗方面的研究进展  

Progress in research on role of bone marrow derived mesenchymal stem cells in treatment of kidney failure

作　　者：王海霞[1] 赵巍[1] 冯业童[2] 刘朋飞[2] 

机构地区：[1]大庆龙南医院药剂科,黑龙江大庆163453 [2]吉林大学药学院生物工程实验中心,吉林长春130021

出　　处：《中国生物制品学杂志》2014年第4期574-577,共4页Chinese Journal of Biologicals

摘　　要：肾衰竭(kidney failure,KF)是临床常见肾脏疾病,常由肾毒性物质或肾脏严重缺血等因素引起,根据其发病时程,可进一步分为急性肾衰竭(acute kidney failure,AKF)和慢性肾衰竭(chronic kidney failure,CKF)。近年来,随着各项医疗技术的发展,许多疾病均得到了有效控制,但是,KF这种疾病尚未得到有效治疗,相关的死亡率也未得到明显改善,其发病率甚至有逐年增高的趋势。目前,相关研究表明,骨髓间充质干细胞(bone marrow derived mesenchymal stem cells,BMSCs)对KF具有一定的治疗作用。本文就近年来BMSCs在KF治疗方面的研究进展作一综述。Kidney failure （KF） is a kind of common clinical kidney disease generally caused by kidney toxic substances, serious kidney isehemia and other factors, which is classified as acute kidney failure （AKF） and chronic kidney failure （CKF） according to the time course of onset. With the development of medical treatment technique, lots of diseases have been controlled effectively in recent years. However, no effective therapy modes have been created to kidney failure which keeps unimproved death rate and increased attack rate. At present, the curative effect of bone marrow derived mesenchymal stem cells （BMSCs） on KF has been reported by researchers. This paper reviews the progress in research on role of BMSCs in treatment of KF in recent years.

关 键 词：骨髓间充质干细胞 肾衰竭 生物治疗 

分 类 号：R692.5[医药卫生—泌尿科学]