血小板相关因子在血栓性疾病中的作用  

Roles of platelet-associated factors in thrombotic disease

作　　者：赵艳芳[1] 刘琳[1] 邬云红[1] 

机构地区：[1]西藏自治区人民政府驻成都办事处医院,四川成都610041

出　　处：《中国生物制品学杂志》2014年第4期578-581,共4页Chinese Journal of Biologicals

基　　金：西藏自治区科技厅(Z2012A03G0700)

摘　　要：血栓性疾病(thrombotic disease)已成为全球人类死亡的主要原因,每年约720万人死于该病。而血小板(blood platelet)的功能与血栓性疾病的发生发展密切相关,如血小板相关组织因子(tissue factor,TF)、Toll样受体(Toll-like receptors,TLRs)、血小板表面Fc受体γ链(Fc receptor gamma-chain)、平均血小板体积(mean platelet volume,MPV)、P选择素(p-selectin)、血小板膜糖蛋白V(glycoprotein V,GPV)以及血小板内皮细胞黏附分子-1(platelet endothelial cell adhesion molecule-1,PECAM-1)等均参与血栓形成过程。本文就血小板相关因子在血栓性疾病中的作用作一综述,为临床心血管疾病的治疗提供参考。Thrombotic disease is the major cause of death worldwide, contributing to over 7. 2 million deaths annually, of which the development is closely associated with the function of platelet. Platelet-associated factors, such as platelet-associated tissue factor, Toll-like receptors, Fc receptor gamma-chain, mean platelet volume, p-selectin, glycoprotein V and platelet endothelial cell adhesion molecule-1, involve the formation of thrombosis. This paper reviews the roles of platelet-associated factors in thrombotic disease so as to provide a reference for the treatment of cardiovascular disease in clinic.

关 键 词：血栓性疾病 血小板 血小板相关因子 

分 类 号：R558[医药卫生—血液循环系统疾病]