金荞麦银纳米粒的制备及其工艺优化研究  

Study on biosynthesis of silver nanoparticles using Fagopyri Dibotryis Rhizoma extract and optimization of synthesis conditions

作　　者：孙文杰[2] 瞿鼎[1] 陈彦[1,2] 袁菱[1] 贺俊杰[2] 

机构地区：[1]国家中医药管理局中药释药系统重点研究室,江苏省中医药研究院中药新型给药系统重点实验室,江苏南京210028 [2]南京中医药大学附属中西医结合医院,江苏南京210023

出　　处：《中国中药杂志》2014年第9期1597-1602,共6页China Journal of Chinese Materia Medica

基　　金：江苏省中医药领军人才项目(LJ200913)

摘　　要：该研究以金荞麦提取液为还原剂和稳定剂制备银纳米粒,并通过考察金荞麦粉末提取时间、银纳米粒合成温度、金荞麦提取液加入量、AgNO3溶液的浓度等不同因素,优选金荞麦银纳米粒形成的最佳工艺,并采用红外光谱仪(FT-IR)、透射电镜(TEM)、动态激光散射(DLS)、X-射线粉末衍射(XRD)对所制银纳米粒进行结构表征和形态学考察。结果显示,制备银纳米粒最佳条件为金荞麦粉末煮沸5 min,提取液(质量浓度0.1 g·mL-1)与1 mmol·L-1AgNO3体积比1∶10,反应温度25℃,反应时间3.5 h。所得银纳米粒形态圆整,分布均匀、性质稳定,平均粒径约(27±2.6)nm,Zeta电位(-34.3±3.2)mV。结果表明该研究所建立的以中药提取液制备银纳米粒的绿色合成方法稳定可行。Silver nanoparticles were synthesized from the extract of Fagopyri Dibotryis Rhizoma and the optimization of synthesis was studied. The absorbance of UV-visible spectroscopy was determined under the different influencing factors such as extracting time of Fagopyri Dibotryis Rhizoma powder, reation temperature of synthesis, volume of Fagopyri Dibotryis Rhizoma extract and concen- tration of AgNO3 to seek the optimization conditions. By means of FT-IR, TEM, DLS and XRD, the silver nanoparticles were charac- terized. The results showed that when the boiling time of Fagopyri Dibotryis Rhizoma powder was 5 rain, resultant temperature was 25 ℃, the volume ratio ofO. 1 g ·mL^-1 Fagopyri Dibotryis Rhizoma extract and 1 mmol· L^-1 AgNO3 was 1 to 10, and the reaction time was 3.5 h, the obtained silver nanoparticles had mean size about 27 nm and Zeta potential about - 34. 3 mV with good uniformity and dispersivity. Therefore, the green synthesis method of silver nanoparticles using extract of traditional Chinese medicine is stable and feasible.

关 键 词：金荞麦提取液 AgNO 银纳米粒 条件优化 

分 类 号：TQ461[化学工程—制药化工]