子宫内膜异位症的三维模型研究进展  

Progress in Three Dimensional Models of Endometriosis

作　　者：梁莉莉[1] 林毅豪 王宁宁[1] 

机构地区：[1]中山大学附属第一医院妇产科,广州510080 [2]中山大学中山医学院

出　　处：《国际妇产科学杂志》2014年第2期98-102,111,共6页Journal of International Obstetrics and Gynecology

基　　金：国家自然科学基金(81170550;30672222);广东省自然科学基金(8151008901000124);广东省科技计划项目(2010B050700009;2007B080701011);广州市科技计划项目(2010Y-C011);广东省医学科学技术研究基金(A2009672);中山大学附属第一医院人才培养计划(2007)

摘　　要：子宫内膜异位症(endometriosis,EMs)即子宫内膜样组织出现在宫腔以外的部位,是目前最常见的育龄期女性妇科疾病。EMs极大地影响了患者的日常生活,而研究者们却对其发病机制了解有限,且目前的治疗策略不能彻底治愈EMs或有不能接受的不良反应。鉴于EMs的发病机制不尽明确,创建人EMs研究模型对该病的研究将扮演重要的角色。总结近年EMs三维模型(three-dimensional models)的建立和发展,同时讨论各种造模方法的具体方法及优缺点,为EMs提供更为仿真的研究模型。Endometriosis （EMs） is the presence of endometrial glandular and stromal cells outside of the uterine cavity , and is the most common disorder in reproductive women. Quality of life for these women is predictable to be negatively affected. For the poor understanding about the pathophysiology of endometriosis ,no current medical therapy has been demonstrated to be effective in eradicating the disease or in preventing it without unacceptable side effects. Concerning about the uncertainties about the pathophysiology of endometriosis ,the establishment of an appropriate human EMs model plays a pivotal role in the study of endometriosis. This review tends to sum up the establishment and development of the endometriosis three-dimensional models （3D models） and assesses the methods and materials,different potential and limitation regarding to endometriosis researches,with the aim of developing novel simulating models for the further study.

关 键 词：子宫内膜异位症 体外研究 模型 动物 三维模型 

分 类 号：R711.71[医药卫生—妇产科学]