Enantioselective extraction of clorprenaline enantiomers with hydrophilic selector of sulfobutylether-β-cyclodextrin by experiment and modeling  

作　　者：周丛山 徐萍 唐课文 蒋新宇 杨涛 张盼良 朱政 

机构地区：[1]College of Chemistry and Chemical Engineering, Hunan Institute of Science and Technology [2]College of Chemistry and Chemical Engineering, Central South University

出　　处：《Journal of Central South University》2014年第3期891-899,共9页中南大学学报（英文版）

基　　金：Projects(21176262,21071052) supported by the National Natural Science Foundation of China;Project supported by the Aid program for Technology Innovative Research Team in Higher Educational Institutions of Hunan Province,China

摘　　要：Enantioselective extraction of hydrophobic clorprenaline （CPE） enantiomers from organic phase to aqueous phases with sulfobutylether-β-cyclodextrin （SBE-β-CD） as the selector was investigated with insight into a number of important process variables, such as the type of organic solvent, concentration of selector, pH, and temperature. Equilibrium of the extraction system was modeled using a reactive extraction modcl with a homogeneous aqueous phase reaction. The important parameters of this model were determined experimentally. The physical distribution coefficients for molecular and ionic CPE were determined as 0.3 and 8.93, respectively. The equilibrium constants of the complexation reaction with SBE-β-CD were determined as 152 and 110 L/mol for R- and S-CPE, respectively. Results show that the experimental data agree with the model predictions perfectly. Comprehensively considering the experiment and model, the extraction conditions are optimized and the best extraction conditions are： pH of 6.0, SBE-β-CD concentration of 0.04 tool/L, and temperature of 5 ℃, providing the enantioselectivity （a） of 1.25, the fraction of R-CPE （φR） in aqueous phase of 0.71 and performance factor （pf） of 0.025.Enantioselective extraction of hydrophobic clorprenaline(CPE) enantiomers from organic phase to aqueous phases with sulfobutylether-β-cyclodextrin(SBE-β-CD) as the selector was investigated with insight into a number of important process variables, such as the type of organic solvent, concentration of selector, pH, and temperature. Equilibrium of the extraction system was modeled using a reactive extraction model with a homogeneous aqueous phase reaction. The important parameters of this model were determined experimentally. The physical distribution coefficients for molecular and ionic CPE were determined as 0.3 and 8.93, respectively. The equilibrium constants of the complexation reaction with SBE-β-CD were determined as 152 and 110 L/mol for R- and S-CPE, respectively. Results show that the experimental data agree with the model predictions perfectly. Comprehensively considering the experiment and model, the extraction conditions are optimized and the best extraction conditions are: pH of 6.0, SBE-β-CD concentration of 0.04 mol/L, and temperature of 5 °C, providing the enantioselectivity(α) of 1.25, the fraction of R-CPE(φR) in aqueous phase of 0.71 and performance factor(pf) of 0.025.

关 键 词：clorprenaline sulfobutylether-fl-cyclodextrin reactive extraction chiral recognition modeling 

分 类 号：TQ460.1[化学工程—制药化工] O658.2[理学—分析化学]