头针治疗急性脑出血家兔空间效应的PWI和MRS研究  

Space effect of scalp acupuncture to acute intracerebral hemorrhage rabbits studied by PWI and MRS

作　　者：王凡[1] 雷慧姝 鲍春龄[3] 詹松华[4] 东贵荣[3] 

机构地区：[1]上海中医药大学针灸推拿学院,上海201203 [2]上海嘉定区南翔医院中医康复科,上海201802 [3]上海中医药大学附属岳阳中西医结合医院针灸科,上海200437 [4]上海中医药大学附属曙光医院放射科,上海201203

出　　处：《中华中医药杂志》2014年第5期1595-1599,共5页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金课题(No.90709030);上海市中医药事业三年行动计划(No.ZYSNXD-CC-MZY005)~~

摘　　要：目的:观察头穴透刺治疗对脑出血家兔病灶侧及对侧脑组织脑血流量及神经物质代谢的影响,验证并探索针刺"空间效应"特性规律及其机制。方法:30只雄性新西兰兔随机分为正常组、模型组和针刺组,每组各10只。自体血二次注血法复制急性脑出血模型。针刺组造模成功后即选取患侧头穴(位置相当于人体"百会"透"太阳"穴)进行治疗,连续治疗3d。疗前、疗后即刻、第3天应用磁共振灌注加权成像(PWI)和磁共振波谱分析(MRS)观察各组家兔双侧脑组织局部血流量(rCBF)和N-乙酰基天门冬氨酸(NAA/Cr)的变化。结果:脑出血模型造模成功后,较正常组双侧脑组织rCBF降低,NAA/Cr减小(P<0.01)。血肿周围较对侧变化更为显著(P<0.05,P<0.01)。针刺治疗后即刻,双侧脑组织rCBF显著升高(P<0.01),治疗3d后双侧脑组织NAA/Cr显著增加(P<0.01)。结论:脑出血损伤具有"抑制性泛化的特点",针刺一侧头穴改善脑出血家兔双侧脑组织局部脑血流量和神经物质代谢障碍,减轻"抑制性泛化损伤",具有空间效应特性规律。Objective： To observe the effect of scalp acupuncture on cerebral blood flow and neural material metabolism on both perihematoma and contralateral tissues of intracerebral hemorrhage rabbits, and to verify the space effects of acupuncture, and to explore its mechanism. Methods： A total of 30 New Zealand rabbits were randomly divided into a normal group （nor）, a model group （mod） and an acupuncture group （acu）, with 10 cases in each group. Self-arterial injection method had been used to copy the ICH rabbit model. After the ICH rabbit model was successfully established, the acupuncture group was treated on scalp acupoint of hemorrhage side, equivalent to Baihui （GV20） through Taiyang （EX-HN5） in human body for three days. Quantitative analysis of 1H-MRS and PWI were used to observe the rCBF and NAA/Cr in both perihematoma and contralateral tissues before, instantly and 3rd day after acupuncture treatment. Results： After the ICH model was established, rCBF and NAA/ Cr of both sides reduced significantly （P〈0.01） compared to normal rabbits, with perihematoma more serious than contralateral tissue （P〈0.05, P〈0.01）. After acupuncture therapy, rCBF increased instantly（P〈0.01） and NAA/Cr increased in 3rd day of both sides. Perihematoma recovered quicker than contralateral tissue （P〈0.01）. Conclusion： The characteristics of intracerebral hemorrhage was weak generalization. Acupuncture on scalp acupoint of hemorrhage side could improve cerebral blood flow and neural material metabolism disorders on both sides of brain tissues, and to reduce the weak generalization injury, which means acupuncture has a special character rule of spacial effect.

关 键 词：磁共振灌注加权成像 磁共振波谱分析 脑出血 空间效应 

分 类 号：R245[医药卫生—针灸推拿学]