安岳县42例HIV/AIDS病人免费抗病毒治疗情况分析  

Analysis of the efficacy of free antiretroviral treatment among 42 HIV/AIDS patients in Anyue county

作　　者：杨洋[1] 韩知峡[2] 代蔚 李利春[1] 

机构地区：[1]安岳县疾病预防控制中心,四川资阳642350 [2]泸州医学院,四川泸州646000

出　　处：《中国艾滋病性病》2014年第4期251-253,共3页Chinese Journal of Aids & STD

摘　　要：目的探讨四川省安岳县艾滋病病毒(HIV)感染者/艾滋病(AIDS)病人(HIV/AIDS病人)抗病毒治疗的效果及相关状况,为艾滋病的综合防治提供基础资料和科学依据。方法采用前瞻性随访研究方法,对HIV/AIDS病人的实验室检查相关结果、治疗方案及随访情况做描述性分析、重复测量方差分析、Logistic回归分析。结果 42例病人治疗前、治疗半年后及治疗1年后,CD+4T淋巴细胞(简称CD4细胞)计数的变化差异有统计学意义(F=307.93,P<0.001);当基线CD4细胞计数<200个/μL时,其出现治疗效果较差的危险性是基线CD4细胞计数≥200个/μL的5.675倍;基线CD4细胞计数<200个/μL,发生艾滋病相关死亡的风险较大。按医嘱定期检查肝功、血常规等的次数,随着治疗时间的延长而逐渐减少。结论抗病毒治疗后,病人身体素质有所提高;基线CD4细胞计数越低,治疗效果就越差;抗病毒治疗病人随着治疗时间的增加,依从性逐渐降低。Objective This study aims to explore the effects and correlative factors of antiretroviral treatment （ART） in HIV/AIDS patients in Anyue, Sichuan province and provide primary data and scientific basis for the comprehensive care of HIV/A1DS. Conclusion The follow-up study was conducted prospectively. Laboratory examinaions, therapeutic regimens and follow-up information were analyzed with descriptive method, repeated measure of ANOVA and logistic regression analysis. Results There were statistical differences in change CD4 cell counts among prior treatment, half a year and one year after treatment （F= 307.93 ,P=0. 001）. The risk of poor efficacy in the group of baseline CD＋ T cell counts less than 200 cells/μL was 5. 675 times higher than that of baseline CD＋ T cell counts 200/μL and above. As time went on, regular examinations such as liver function and blood routine test decreased. Conclusion ART is helpful in improving health of HIV/AIDS patients. The lower the baseline CD4＋ T cell counts, the poorer the treatment effects. The adherence of patients decreases gradually with the increase of therapy time,

关 键 词：艾滋病病毒感染者 艾滋病病人 CD4淋巴细胞 抗病毒治疗 效果 

分 类 号：R512.91[医药卫生—内科学]