呋噻米对急进高原大鼠血气影响  

Effect of Furosemide on Blood Gas of Rats after Acute Exposure to High Altitude

作　　者：王延玲[1,2] 王荣[1,2] 谢华[1] 李文斌[1] 马骏[1,2] 陶锐[1,2] 鹿辉[1] 贾正平[1,2] 

机构地区：[1]兰州军区兰州总医院全军高原损伤防治重点实验室,甘肃兰州730050 [2]兰州大学药学院,甘肃兰州730000

出　　处：《解放军药学学报》2014年第2期132-134,共3页Pharmaceutical Journal of Chinese People's Liberation Army

基　　金：国家科技部重大资助项目;No.2008ZXJ09014-010;全军医药科研"十二五"重点项目;No.BWS12J012;全军医药科研"十二五"面上项目;No.CWS11C231

摘　　要：目的探讨急进4300 m海拔条件下呋噻米对大鼠血气的影响。方法实验Wistar雄性大鼠40只,分为A组(平原对照组)、B组(高原对照组)、C组(高原呋噻米组)及D组(高原乙酰唑胺组)4组。在各处标准饲养3 d后腹主动脉取血测定血气。结果各组血气结果有不同程度的改变。C组与B组相比,PO2、HCT、K+、ctHb、CB及ctO2均下降(P<0.05);SatO2百分比显著升高(P<0.05),机体有一定程度的呼吸性碱中毒或代谢性酸中毒。结论在4300 m海拔低氧低气压条件下机体的血气发生一定程度的改变,应用呋噻米能一定程度改善大鼠缺氧状态。Objective To investigate the effect of furosemide at altitude of 4300 m on blood gas in rats. Meth-ods 40 Wistar male rates were randomly divided into 4 groups ： group A （ normal control group）, group B （ high altitude control group）, group C （high altitude furosemide group） and group D （high altitude acetazolamide group）. All the rates were anesthetized after they were standardly raised for three days, followed by detection of their blood gas. Re-suits Blood gas in each group was changed to different extents. Respiratory alkalosis and metabolic acidosis occurred. Conclusion The altitude 4300 m has some effect on blood gas and furosemide can protect tissues from damage.

关 键 词：低氧低气压 血气 呋噻米 低氧血症 

分 类 号：R962[医药卫生—药理学]