血清脂联素、TNF-α、CRP在脓毒症患者中的临床应用价值分析  

Clinical application value analysis of serum adiponectin,TNF-α,CRP in patients with sepsis

作　　者：王永芹 李治国[2] 

机构地区：[1]西宁市第一人民医院检验科,西宁810003 [2]中国医科大学附属第四医院检验科,沈阳110032

出　　处：《中国免疫学杂志》2014年第4期528-530,共3页Chinese Journal of Immunology

摘　　要：目的:探讨血清脂联素、TNF-α、CRP在脓毒症患者中的临床应用价值及其对病情的预测作用。方法:选取2012年5月至2013年5月本院收治的脓毒症患者48例为研究对象,同时选取40例正常体检者为对照组,对比分析两组及不同病情脓毒症患者血清脂联素、TNF-α、CRP水平。结果:与对照组相比,脓毒症组患者TNF-α、CRP水平显著升高,而血清脂联素水平显著下降,差异有统计学意义(P<0.05)。随着急性脓毒症死亡风险(MEDS)评分的升高,患者死亡率随之升高,TNF-α、CRP水平也随之升高,而血清脂联素水平显著下降,差异有统计学意义(P<0.05)。死亡组患者TNF-α、CRP水平显著高于生存组患者,而血清脂联素水平低于生存组,差异有统计学意义(P<0.05)。结论:血清脂联素水平下降与脓毒症组病情进展有密切关系,其发生机制可能与炎症因子水平上升介导炎症反应有关。通过测定血清脂联素、TNF-α、CRP水平能有效预测脓毒症患者病情的进展,具有一定的临床应用价值。Objective ：To investigate the clinical application and disease effects of serum adiponectin, TNF-α, CRP in patients with sepsis. Methods： 48 patients with sepsis were selected for study from May 2012 to May 2013 and 40 normal volunteers were se- lected as the control group. The levels of sepsis adiponectin, TNF-α, CRP of two groups and different disease groups were compared. Results： The levels of sepsis patients TNF-α, CRP of serum group were increased than control group （ P 〈 0.05 ）. The levels of in- creasing, TNF-α, CRP of the risk of death from acute sepsis （MEDS） score increased mortality, while serum adiponectin levels were significantly decreased, the differences were statistically significant （ P 〈 0.05 ）. The level of TNF-α, CRP of Death group were higher than those in Live group, the difference was statistically significant （ P 〈 0.05 ）. Conclusion： Serum adiponectin levels decreased with sepsis progression is closely related to its mechanism may be associated with increased levels of inflammatory cytokines mediated inflam- matory reaction. By measuring serum adiponectin, TNF-α, CRP levels can predict disease progression in patients with sepsis, has some clinica/ value.

关 键 词：脂联素 TNF-Α 脓毒症 

分 类 号：R4[医药卫生—临床医学]