热熔压敏胶基质结构对药物释放性能的影响  

Profiles of Drug Release from Hot-Melt Pressure Sensitive Adhesive: Effect of Matrix Structure

作　　者：王承潇[1,2] 韩伟[2] 刘然[2] 汤秀珍 

机构地区：[1]昆明理工大学生命科学与技术学院,云南昆明650500 [2]华东理工大学药学院,上海200237 [3]国家中药制药工程技术研究中心,上海201203

出　　处：《高校化学工程学报》2014年第1期38-45,共8页Journal of Chemical Engineering of Chinese Universities

基　　金：国家"十一五"科技支撑计划课题(2008BAI53B075)

摘　　要：为了研究热熔压敏胶基质结构对药物的释放性能的影响,实验中以不同牌号的苯乙烯-异戊二烯-苯乙烯嵌段聚合物为主体材料,制备了具有不同结构的压敏胶基质。同时选择了水杨酸甲酯、辣椒素、盐酸苯海拉明为模型药物,考察了药物在不同基质中的释放行为。研究结果表明,药物在基质中以分散或溶解状态分布,浓度为2%时无结晶析出。药物在基质中的扩散决定了药物的释放速率。对于不同药物,在基质中溶解度大,药物的扩散系数高,则释放速率快。对于同种药物在不同基质中的释放,软硬两相分布均匀的嵌段聚合物能够提供较多的自由体积,由其制备的基质具有较低的储能模量平台和较低的黏度,可以提高药物在基质中的扩散系数,导致释放速率加快。In order to investigate the effect of matrix structure on drug release profiles, hot-melt pressure sensitive adhesives were made with different styrene-isoprene-styrene block copolymers. Methyl salicylate, capsaicin, and diphenhydramine hydrochloride were selected as model drugs to perform the release experiment. The result shows that the drugs exist in a dispersed or dissolved state in the matrix and no crystallization occurs with the drug concentration up to 2%. The drug release profile is controlled by the diffusion mechanism in the matrix. The drug with high solubility in the matrix gives a high diffusion coefficient, and leads to have a fast release behaviors. On the other hand, the block copolymer with homogeneous and mesh-like microstructures possesses more free volume of intermolecular, which causes the reduction of the energy storage modulus and viscosity of the matrix and results in a higher diffusion rate of the drugs.

关 键 词：热熔压敏胶 苯乙烯-异戊二烯-苯乙烯嵌段聚合物 骨架型经皮给药系统 药物释放 

分 类 号：TQ436.3[化学工程] TQ436.4