多巴胺神经系统显像分子探针研究  

Recent advances in PET tracers for imaging of the dopaminergic system

作　　者：乔晋萍[1] 乔洪文[2] 武仙英[1] 邓艾芳[1] 朱霖[1,3] 

机构地区：[1]北京师范大学化学学院,放射性药物教育部重点实验室,北京100875 [2]首都医科大学宣武医院,北京100053 [3]北京脑重大疾病研究院帕金森病研究所,北京100053

出　　处：《生命的化学》2014年第2期154-165,共12页Chemistry of Life

摘　　要：多巴胺神经系统在神经退行性疾病和精神紊乱中充当了主要角色,比如帕金森病、亨廷顿病、迟发性运动障碍、精神分裂症。以多巴胺能神经系统为靶点的PET显像可以了解多巴胺合成、受体密度和状态改变,为神经系统疾病的早期诊断、疗效监测、发病机制以及脑认知功能的研究等方面提供客观、科学的观察手段。本文综述了以多巴胺受体、多巴胺转运体及囊泡单胺转运体为靶点的PET显像剂的研究进展。The dopaminergic system plays a major role in neurological and psychiatric disorders, such as Parkinson＇s disease, Huntington＇s disease, tardive dyskinea and schizophrenia, Knowledge on altered dopa mine synthesis, receptor densities and status are important for understanding the mechanisms underlying the pathogenesis and therapy of diseases, PET provides a non-invasive tool to investigate these features in vivo by using suitable radiopharmaceuticals, To investigate presynaptic function, PET-tracers have been developed to measure dopamine synthesis and transport, This paper gives an overview of the PET-tracers targeting on dopamine receptors, DAT and VMAT2, and the development of new lead compounds as potential PET-tracers by medicinal chemistry,

关 键 词：正电子发射计算机断层扫描 多巴胺转运体 多巴胺受体 囊泡单胺转运体 

分 类 号：R341[医药卫生—基础医学]