同源结构域相互作用蛋白激酶2(HIPK2)研究进展  

Research progress in homeodomain interacting protein kinase 2

作　　者：王欢[1] 王允山[2] 吉爱国[1,2] 

机构地区：[1]山东大学药学院,济南250012 [2]山东大学海洋学院,威海264209

出　　处：《生命的化学》2014年第2期257-261,共5页Chemistry of Life

基　　金：山东省自然科学基金项目(ZR2010CM049)

摘　　要：同源结构域相互作用蛋白激酶2(HIPK2)是一种定位于细胞核内的丝氨酸/苏氨酸蛋白激酶。HIPK2可以诱导和抑制转录,亦能调节细胞分化、增殖及凋亡。HIPK2经过泛素化、小泛素样修饰物(SUMO)化、乙酰化、磷酸化等翻译后修饰来发挥其生物功能。研究表明,HIPK2磷酸化p53、甲基化CpG结合蛋白2(methyl CpG binding protein 2,MeCP2)及早幼粒细胞性白血病蛋白(promyelocytic leukemia protein,PML)促进细胞凋亡。本文较为详细的阐述了有关HIPK2的研究进展,特别是近5年的研究成果。Homeodomain-interacting protein kinase 2 （HIPK2） is a serine/threonine kinase, which is localized mainly in nuclei. HIPK2 can induce or inhibit transcription, and regulate cell differentiation, proliferation and apoptosis. Differential posttranslational modifications （PTMs） have been identified to finely regulate HIPK2 functions. They can be either chemical moieties （such as acetylation, phosphorylation, and other marks） or proteins （such as SUMO, ubiquitin, etc.）. Studies have shown that p53, MeCP2, PML are phosphorylated by HIPK2 to promote apoptosis. In this review, research progresses in HIPK2 are described, especially in the recent five years.

关 键 词：HIPK2 增殖 分化 凋亡 

分 类 号：Q55[生物学—生物化学]