补肾益寿胶囊药材水提工艺中大孔吸附树脂的优选  

Preparation of Water Extract of Bushen Yishou Capsules with Macroporous Resin

作　　者：金思岑[1] 覃瑶[1] 孟慧杰[1] 秦少容[1] 罗维早[2] 孙建彬[2,3] 丁刚[2] 王欣[2] 

机构地区：[1]太极集团有限公司,重庆401147 [2]重庆市中药研究院,重庆400065 [3]成都中医药大学药学院,成都611730

出　　处：《中国药房》2014年第19期1754-1757,共4页China Pharmacy

基　　金：国家科技部"十一五"科技重大专项"重大新药创制"项目(No.2009ZX09313-037);重庆市科研院所创新能力建设计划项目(No.CSTC;2012pt-kyys10004;CSTC;2012pt-kyys10001)

摘　　要：目的:优选补肾益寿胶囊药材水提工艺中的大孔吸附树脂。方法:建立补肾益寿胶囊5味药材水提液高效液相色谱(HPLC)指纹图谱,以选定的10个色谱峰为指标,并结合70%乙醇洗脱液干膏收率优选大孔吸附树脂型号。结果:Seplite LX-66型大孔吸附树脂对10个指标成分具有较好的吸附性能和解吸效果,且70%乙醇洗脱液干膏收率最低(0.34%)、精制效果最好。结论:Seplite LX-66型大孔吸附树脂综合性能良好,适用于补肾益寿胶囊药材水提液的精制。OBJECTIVE ： To optimize for macroporous resin in the technology of Bushen yishou capsules water extract. METH- ODS： With the help of HPLC fingerprint chromatogram water extract of 5 ingredients in Bushen yishou capsules, the optimal mac- roporous resin was selected with 10 chromatographic peaks and the yield of dry extract from 70% ethanol eluant as index. RE- SULTS： The study had shown that Seplite LX-66 macroporous resin was optimal macroporous resins for refining the Bushen yishou capsule water extract by good adsorption and de-adsorption property for ten index ingredients and the yield of dry extract of 70% ethanol eluant was the lowest. CONCLUSIONS： Seplite LX-66 macroporous resin show excellent comprehensive performance that could be available for refining process of water extract from Bushen yishou capsules.

关 键 词：补肾益寿胶囊 精制 大孔吸附树脂 

分 类 号：R284[医药卫生—中药学] R286[医药卫生—中医学]