茯苓改善学习记忆及镇静催眠作用研究  

Research on Improving Ability of Learning and Memory of Poria Cocos and Its Sedative and Hypnotic Effect

作　　者：李明玉[1] 徐煜彬[1] 徐志立[1] 陈静[1] 窦德强[1] 

机构地区：[1]辽宁中医药大学,辽宁大连116600

出　　处：《辽宁中医药大学学报》2014年第5期25-26,共2页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：国家重点基础研究计划(973计划)项目(2013CB531803);辽宁省高等学校创新团队课题(LT2013020)

摘　　要：目的:研究茯苓改善学习记忆及镇静催眠的作用。方法:采用morris水迷宫实验和戊巴比妥钠协同催眠实验分别评价茯苓改善学习记忆与镇静催眠的作用。结果:高剂量与中剂量茯苓水提液能明显缩短苯巴比妥钠模型小鼠2 min内达到终点平台的潜伏期,并且能显著增加苯巴比妥钠模型小鼠在平台所在象限的时间和行程;茯苓高剂量组能明显增加小鼠睡眠时间和小鼠入睡只数,提高入睡率。结论:茯苓能改善苯巴比妥钠所致记忆障碍小鼠的学习记忆能力,也具有明显镇静催眠作用。Objective ： To study the effects of Poria cocos on improving learning and memory and its sedative and hypnotic effect. Methods： Morris water maze test and coordination function with pentobarbital sodium were used to evaluate the improvment of learning and memory and sedative and hypnotic effect. Results ： The decoction of Poria cocos in high-dose and medium-dose can both shorten latency in acquired learning and memory disorders induced by pentobarbital sodium within 2 min significantly and can increase the time and travel within the platform quadrant of pool significantly ; high-dose group can increase sleeping time and the number of sleeping mice and also can improve sleeping rate significantly. Conclusion ： Poria cocos can improve mice＇s learning and memory dysfunction induced by pentobarbital sodium, and is effective in inducing sedative and hypnotic effects.

关 键 词：茯苓水提液 学习记忆 镇静催眠作用 

分 类 号：R338[医药卫生—人体生理学]