2012年北京市健康人群流行性乙型脑炎抗体水平监测  

Serologic survey of Japanese B encephalitis in healthy people of Beijing, 2012

作　　者：曾阳[1] 李仁清[1] 李晓梅[1] 王瑜[1] 

机构地区：[1]北京市疾病预防控制中心免疫规划所,北京100013

出　　处：《国际病毒学杂志》2014年第2期63-65,共3页International Journal of Virology

摘　　要：目的 了解北京市健康人群流行性乙型脑炎（乙脑）抗体水平及其分布特点.方法 以北京市全部健康人群作为抽样总体,随机选择7个区县,分＜1岁、1-4岁、5-9岁、10-14岁、15-19岁、20-24岁、25-29岁、30-34岁、35-39岁、≥40岁10个年龄组,共对1676名监测对象调查采样,采用蚀斑减少中和试验法检测乙脑中和抗体.结果 乙脑抗体总体阳性率为74.8％,不同户籍、不同性别研究对象间乙脑抗体阳性率无统计学差异.＜1岁组儿童阳性率最低（27.9％）;近郊区人群乙脑抗体阳性率明显高于城区和远郊区县（x2 =29.5,P＜0.01）;民工乙脑抗体阳性率明显高于其他职业人群（x2 =7.3,P＜0.01）.结论 北京市健康人群感染乙脑病毒的概率和频次降低;及时接种乙脑减毒活疫苗对保护＜1岁组儿童具有重要作用.此外应警惕乙脑发病向大年龄推移.Objective To study the antibody and distribution of Japanese encephalitis virus （JEV） among healthy people in Beijing. Methods 7 national surveillance districts were selected and divided into ten groups as 〈1, 1-4, 5-9, 10-14, 15-19, 20-24, 25-29, 30-34, 35-39 and ≥40 years old. 1676 people were sampled as monitoring subjects. Neutrahzing antibody was used to detect JE IgG. Results The positive antibody rate of JE was 74. 8%. There was no statistical difference either in gender or census register. 〈 1 year old age group showed the lowest positive antibody rate （ 27.90% ）. The positive antibody rate in suburb was higher than that in urban area and outer suburban district（x2 = 29.5, P 〈 0. 01 ）. Positive rate was higher in migrant labor workers than in other professions （X2 = 7.3, P 〈 0. 01 ）. Conclusions The frequency and probability of healthy people infected with JE was decreasing. Timely vaccination of JEV is very important in protecting children below 1 year old. We should be on guard against the trend of adult JE.

关 键 词：流行性乙型脑炎 抗体水平 监测 

分 类 号：R512.32[医药卫生—内科学]