α-氨基-3羟基-5-甲基4-异恶唑丙酸受体亚基GluR2在缺血性脑损伤中的作用  

The role of the GluR2 α-amino-3-hydroxy-5-methyHsoxazole-4-propionate receptor channel in ischemic cerebral injury

作　　者：刘望宇 李立亚[1] 高杨[1] 陈绍洋[1] 王强[1] 

机构地区：[1]西安第四军医大学西京医院麻醉科,710032

出　　处：《国际麻醉学与复苏杂志》2014年第5期473-476,共4页International Journal of Anesthesiology and Resuscitation

摘　　要：背景谷氨酸离子型受体α-氧基-3羟基-5-甲基4异恶唑丙酸（α-amino-3-hydroxy-5-mnethylisoxazole-4-propionate．AMPA）在缺血性脑损伤的发生发展过程中起重要作用。AMPA受体的GluR2亚基对其Ca2＋通透性的调控逐渐受到人们的重视，这为缺血性脑损伤的治疗提供了新的契机。目的探讨AMPA受体GluR2亚基在缺血性脑损伤过程中的调控作用，寻找新的缺血性脑损伤的治疗靶点。内容综述缺血性脑损伤后AMPA受体Ca2＋通透性与GluR2亚基的关系及影响因素。趋向单纯针对GluR2亚基，阻断缺血，缺氧后因此产生的钙超载，这将成为治疗脑中风可能的有效靶点。Background Ionotropic glutamate receptors （iGluRs）, such as α-amino -3 -hydroxy -5 -methylisoxazole -4 - propionate （AMPA） receptors, play an important role in the development and progress of ischemic cerebral injury. More attention has been paid to the regulation of AMPA receptor GluR2 subunit in Ca2＋-Permeability of AMPA. Study in this regard will provide a new opportunity on the prevention and treatment of ischemic stroke. Objective To find a new therapeutic target of ischemic injury, we reviewed the role of the AMPA receptor GluR2 subunit in stroke. Content This review summarizes the relationship between GluR2 subunits and Ca2＋-Permeability of AMPA as well as the other related factors. Trend Attenuating intracellular calcium overload via blockage of GluR2 subunits will become an effective therapeutic target for treatment of ischemic injury.

关 键 词：α氧基-3羟基-5-甲基4异恶唑丙酸受体 GluR2亚基 缺血性脑损伤 

分 类 号：R743.31[医药卫生—神经病学与精神病学]