1056例HIV/AIDS患者中药治疗半年CD4＋细胞计数变化分析  

CD4＋ cell count analysis on 1 056 cases of HIV/AIDS treated with TCM for half a year

作　　者：赵莹莹[1] 张启明[2] 王义国[2] 于东林[2] 方路 

机构地区：[1]广西中医药大学,南宁530001 [2]中国中医科学院中医临床基础医学研究所,北京100700 [3]云南中医中药研究院艾滋病临床研究室,昆明530001

出　　处：《国际中医中药杂志》2014年第5期415-418,共4页International Journal of Traditional Chinese Medicine

基　　金：“十二五”国家科技重大专项课题（项目编号：2012ZXl0005010-004）

摘　　要：目的：探讨中药治疗半年的HIV/AID患者CD4＋细胞计数的变化规律。方法根据CD4＋细胞计数将患者分为4个临床分期，采用中药治疗。观察CD4＋细胞在治疗前和治疗半年后的变化，并分析不同临床分期CD4＋细胞的变化。结果①秩和检验显示，采用中医药治疗后CD4＋细胞有明显提高。治疗前 CD4＋细胞平均数为（317.76±175.61）个/mm3，治疗后为（350.60±175.92）个/mm3（P＜0.01）。②Ridit 分析结果：Ⅰ期患者平均 R＝0.614，95%置信区间为（0.5702，0.6579）；Ⅱ期患者平均 R＝0.575，95%置信区间为（0.5439，0.6062）；Ⅲ期患者平均R＝0.460，95%置信区间是（0.4347，0.4849）；Ⅳ期患者平均 R＝0.428，95%置信区间为（0.3971，0.4589）。中药治疗艾滋病Ⅲ期、Ⅳ期效果和Ⅰ期、Ⅱ期效果有差异，Ⅰ期、Ⅱ期效果不明显，Ⅲ期、Ⅳ期效果明显。Ⅰ期和Ⅱ期略有差异，Ⅲ期和Ⅳ期略有差异。结论中药可扶助HIV/AID患者的正气。Objective To Analyze CD4＋ cell count which embodies curative effect in HIV and patients with AIDS, who have treated with TCM for half a year. Methods According to CD4＋cell count, the patients were divided into 4 phases. Their CD4＋cell count were analyzed before and after the treatment. Results 1.Rank sun test showed that CD4＋cell count were significantly improved in people who used TCM treatment. On the whole, CD4＋cell count was（317.76±175.61） in 1 cu mm before treatment, which was（350.60±175.92） in 1 cu mm after treatment, P〈0.01. 2. Ridit showed that patients whose CD4＋cell count more than 500 were in phase I. Their R=0.614, and the 95%confidence interval was 0.5702 to 0.6579. Patients whose CD4＋cell count more than 350 and less than 500 were in phase II. Their R=0.575, and the 95%confidence interval was 0.5439 to 0.6062. Patients whose CD4＋cell count more than 200 and less than 350 were inphase III. Their R=0.460 and the 95%confidence interval was 0.4347 to 0.4849. Patients whose CD4＋cell count less than 200 were in phase IV. Their R=0.428, and the 95%confidence interval was 0.3971 to 0.4589. There was no overlap between phase III, phase IV and phase I, phase II in 95% confidence interval. Conclusion TCM has the advantages in strengthening vital qi, but that is worse than western medicine in effort of expelling pathogen.

关 键 词：艾滋病 中医药 CD4+细胞 

分 类 号：R259[医药卫生—中西医结合]