抗坏血酸有机锗倍半氧化物油水分配系数的测定  

Determination content and oil-water partition coefficient of ascorbic acid organic germanium sesquioxide

作　　者：高姍姍 闫静[1] 贾桂芝[1] 张立剑[1] 

机构地区：[1]黑龙江中医药大学药学院,黑龙江哈尔滨150040 [2]黑龙江农垦职业学院,黑龙江哈尔滨150025

出　　处：《分子科学学报》2014年第2期131-135,共5页Journal of Molecular Science

基　　金：黑龙江省教育厅科研项目(12511517)

摘　　要：抗坏血酸有机锗倍半氧化物是一种抗肿瘤药物。通过建立了紫外分光光度法测定抗坏血酸有机锗倍半氧化物含量的方法,用摇瓶法测定其油水分配系数。建立标准曲线方程A=5.312 9C+0.043 0,检测波长217nm,回收率为98.28%,油水分配系数P=0.37。应用摇瓶-紫外分光光度法,能够准确测定抗坏血酸有机锗倍半氧化物的油水分配系数,为脂质体处方设计提供参考。Ascorbic acid organic germanium sesquioxide is an antineoplastic drug. The concentration of ascorbic acid organic germanium sesquioxide was measured by UV method. To determine the oil--wa- ter partition coefficient of ascorbic acid organic germanium sesquioxide by the shake flask. Standard curve equation was A=5. 312 9C＋0. 043 0 and wavelength detection was 217 nm, and rate of recovery was 98.28% and the oil-water partition coefficient was 0.37. The shake flask-ultraviolet spectropho- tometry method can be used to determine the oil-water partition coefficient of ascorbic acid organic germanium sesquioxide accurately, as a reference for design liposome formulation.

关 键 词：抗坏血酸有机锗倍半氧化物 油水分配系数 

分 类 号：O643[理学—物理化学]