酸枣仁黄酮对记忆障碍小鼠学习记忆能力的影响  

Effects of Semen Flavonoids on Ability of Learning and Memory in Mice with Memory Disorder

作　　者：王丽娟[1,2] 张彦青[1,2] 王勇[2] 邓振涛 王雪霖[2] 

机构地区：[1]天津市食品生物技术重点实验室,天津300134 [2]天津商业大学生物技术与食品科学学院,天津300134

出　　处：《中国中医药信息杂志》2014年第5期53-55,60,共4页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国家自然科学基金(311012352012-2014)

摘　　要：目的观察酸枣仁黄酮对小鼠学习记忆能力的影响,并探讨其作用机制。方法将72只小鼠按体质量分层随机分为正常组、模型组、吡拉西坦组及酸枣仁黄酮低、中、高剂量组,分别于第11日腹腔注射东莨菪碱(1.5 mg/kg)制作记忆获得障碍模型,第12日乙醇灌胃(35%,10 mL/kg)制作记忆再现障碍模型。各给药组给予相应药物灌胃,连续给药12 d。采用避暗法和迷津法观察酸枣仁黄酮与吡拉西坦对记忆障碍小鼠学习记忆能力的改善作用。结果酸枣仁黄酮能不同程度地延长小鼠的潜伏期,减少错误次数,缩短遭电击的时间。酸枣仁黄酮高剂量组各项指标与模型组比较,差异有统计学意义(P<0.05),而与吡拉西坦组比较,差异无统计学意义(P>0.05)。结论酸枣仁黄酮能改善小鼠学习记忆能力。Objective To reserch the effects of Semen flavonoids on the ability of learning and memory in mice. Methods Totally 72 mice were randomly divided into normal group, model group, piracetam group and Semen flavonoids low-, medium-, high-dose group. On the eleventh day, scopolamine （1.5 mg/kg） was intraperitoneally injected to induce memory aquirement disorder, and on the twelfth day, alcohol （35%, 0.1 mL/kg） was intragastrically administrated to induce memory reappearance disorder. The mice were given corresponding drugs for 12 days. Using dark avoidance test and maze test, the effects of Semen flavonoids and piracetam on ability of learning and memory were observed and compared. Results Semen flavonoids could prolong the latent period, reduce the erroneous times and shorten total time of lightning stroke. The indicators were significant different between Semen flavonoid high-dose group and model group （P〈0.05）. While there was no significant difference between Semen flavonoids and piracetam （P〉0.05）. Conclusion Semen flavonoids could improve the learning and memory abilities of mice with memory disorder.

关 键 词：酸枣仁黄酮 记忆获得障碍 记忆再现障碍 小鼠 

分 类 号：R285.5[医药卫生—中药学]