多指标正交试验优选抗痨清肺颗粒提取工艺  

ptimization of Extraction Process of Kanglao Qingfei Granules by Orthogonal Test with Multi-indexes

作　　者：罗纯清 夏新华[1] 谭喜平[1] 彭买姣[1] 曾建国[2] 刘艳科[2] 

机构地区：[1]湖南中医药大学药学院,湖南长沙410208 [2]长沙市中心医院,湖南长沙410004

出　　处：《中国中医药信息杂志》2014年第5期91-94,共4页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国家科技重大专项-艾滋病和病毒性肝炎等重大传染病防治(2013ZX10005004-003)

摘　　要：目的优选抗痨清肺颗粒的最佳提取工艺。方法以岩白菜素提取转移率、总多糖浸出率、浸膏得率为评价指标,采用正交试验设计考察浸泡时间、加水量、提取时间对提取工艺的影响。结果抗痨清肺颗粒的最佳提取工艺条件为:加水浸泡1.0 h,回流提取2次,加水量分别为10、8倍量,提取时间分别为2.5、2.0 h。结论优选出的提取工艺简单、稳定,可为抗痨清肺颗粒的工业化生产提供依据。Objective To optimize the extraction process of Kanglao Qingfei granules. Methods Orthogonal test design was used to study the influence of soaking time, water content, extraction time on extraction technology with bergenin＆#39;s extraction rate, total polysaccharides＆#39;s extraction rate and extract yield as evaluation indexes. Results The optimum extraction process conditions were as follows：the raw materials were immersed in water for 1.0 h and extracted two times under reflux, and the ratio of water volume to raw materials weight was 10 and 8 （mL/g）, and extraction time was 2.5 h and 2.0 h, respectively. Conclusion The optimized extraction process was simple and stable, which can provide foundation for industrial production of Kanglao Qingfei granules.

关 键 词：抗痨清肺颗粒 正交试验 提取工艺 岩白菜素 多糖 

分 类 号：R283.5[医药卫生—中药学]