尼可地尔在持续性肌钙蛋白Ⅰ弱阳性心绞痛患者中的作用  

Effect of Nicorandil on unstable angina patients with persistent weak positive for troponin-I

作　　者：朱元州[1] 胡量子[1] 卢思稼[2] 杜雄兵 常超[4] 田莉[5] 冯义柏[5] 

机构地区：[1]武汉科技大学附属天佑医院重症医学科,湖北武汉430064 [2]海南省人民医院心内科 [3]武钢总医院心内科 [4]邯郸市第一医院心内科 [5]华中科技大学同济医学院附属协和医院

出　　处：《心血管康复医学杂志》2014年第2期197-199,共3页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:探讨尼可地尔在持续性肌钙蛋白I(TnI)弱阳性不稳定型心绞痛患者中的作用。方法:选择伴有持续性肌钙蛋白I(TnI)弱阳性的不稳定性心绞痛患者111例,随机分为对照组(55例,接受常规治疗)和干预组(56例,在常规治疗基础上加用尼可地尔片(5mg,3次/d);观察,比较两组患者治疗1周内胸痛缓解情况,3个月内因胸痛加重的再住院情况,1年内心源性死亡情况。结果:与对照组比较,干预组1周内两组症状缓解率显著上升(63.6%比91.1%,χ2=11.97,P=0.0005);3个月内胸痛加重再发住院显著减少(56.4%比19.6%,χ2=15.91,P=0.0001);但1年内两组心源性死亡率无显著差异(5.5%比8.9%,χ2=0.50,P=0.4792)。结论:尼可地尔可明显改善持续性TnI弱阳性不稳定型心绞痛患者的症状,而且减少患者因心绞痛加重的再住院率,但一年内死亡率两组没有明显差别。Objective：To discuss effect of nicorandil on unstable angina patients With persistent Weakly positive for troponin I （TnI）.Methods：A total of 111 unstable angina patients With persistent Weakly positive for TnI Were randomly divided into control group （received routine treatment,55 cases） and intervention group （received nic-orandil 5mg,3 times/d based on routine treatment,56 cases）.The relief of chest pain in one Week,the recurrent hospitalization for chest pain aggravation in 3 months and the cardiac mortality rate in one year betWeen tWo groups Were observed in tWo groups. Results：Compared With control group,the relief of angina pectoris in one Week （63.6% vs. 91.1%,χ^2=11.97,P=0.0005）significantly increased,re-hospitalization for chest pain aggravation in three months （56.4% vs.19.6%,χ^2=15.91,P=0.0001）significantly decreased in intervention group;but cardiac mortality rate during one year betWeen tWo groups Was no significant difference （5.5% vs. 8.9%,χ^2=0.50,P=0.4792）.Conclusion：Nicorandil can significantly reduce the unstable angina and re-hospitalization for chest pain aggravation in patients With persistent Weakly positive for TnI,but there Was no significant difference in reducing mortality Within one year betWeen tWo groups.

关 键 词：冠状动脉疾病 肌钙蛋白 尼可地尔 

分 类 号：R541.75[医药卫生—心血管疾病]