磁辅助生物反应器研究进展  

Research progress of magnetically assisted bioreactor

作　　者：林檬[1] 陈国[1] 赵珺[1] 

机构地区：[1]华侨大学化工学院生物工程与生物技术系,福建厦门361021

出　　处：《化工进展》2014年第5期1252-1258,1320,共8页Chemical Industry and Engineering Progress

基　　金：国家自然科学基金(20906035);华侨大学中青年教师科研提升资助计划(ZQN-PY109)项目

摘　　要：磁辅助生物反应器通过辅助磁场直接控制磁性生物载体的运动,有效改善传质及颗粒间的相对运动,兼具固定床、悬浮床、移动床及流化床反应器的优点,具有广阔的应用前景。本文首先从磁性材料、载体材料及构建方法的角度介绍了各类磁性生物载体的特征;总结了轴向电磁场、径向电磁场、永磁体磁场的构建原理及方法;对磁辅助搅拌罐反应器、磁辅助固定床反应器、磁辅助流化床反应器、磁稳流化床反应器的结构特点及其在生化过程中的应用进行了阐述。最后指出磁辅助生物反应器的研究仍停留在实验室水平,其发展有赖于良好生物亲和性的磁生物载体的开发、可控均一辅助磁场的放大及反应器的优化设计。Magnetically assisted bioreactors directly control the motion of magnetic bio-supports by assisting magnetic field,which improves mass transfer and relative motion between catalyst particles and can be combined with the advantages of fixed-bed,slurry-bed,moving-bed and fluidized-bed reactors. In this paper,magnetic bio-supports are characterized from three aspects,including magnetic material,carrier material and construction method;basic principles for construction of axial/transverse electromagnetic field and permanent magnetic field are summarized;configurations of magnetically assisted stirred reactor,magnetically assisted fixed-bed,magnetically assisted fluidized-bed and magnetically stabilized fluidized-bed reactor as well as their applications in biological and chemical processing are presented. Finally,research of magnetically assisted bioreactor is still in the laboratory, and further development asks for novel bio-compatible magnetic supports,controllable homogeneous large-scale assisted magnetic field and more creative reactor design.

关 键 词：生物反应器 固定化 生物载体 磁场 流化床 

分 类 号：Q815[生物学—生物工程]