微波辅助合成5-[4-(4-溴代丁氧基)苯基]-10,15,20-三对甲氧基苯基卟啉  

Microwave-assisted synthesis of 5-[4-(4-bromobutoxy)phenyl]-10,15,20-tri-methoxyphenyporphyrin

作　　者：孙福强[1,2] 梅文杰[2] 崔英德[3] 

机构地区：[1]广东工业大学轻工化工学院,广东广州510090 [2]广东药学院药科学院,广东广州510006 [3]广州科技职业技术学院,广东广州510550

出　　处：《化工进展》2014年第5期1296-1299,共4页Chemical Industry and Engineering Progress

摘　　要：探讨采用微波辅助合成尾式卟啉(p-BrTMOPP)的制备工艺及其影响因素。以吡咯、对羟基苯甲醛和对甲氧基苯甲醛为原料,以丙酸为溶剂,制备得到p-HTMOPP;以1,4-二溴丁烷为原料,微波辅助加热条件下制备得到目标化合物尾式卟啉p-BrTMOPP;目标产物经过UV-vis、IR、ESI-MS等方法表征。在90℃、DMF溶剂条件下微波辐射加热30min,快速高效得到目标化合物,反应产率89.2%。和传统加热方法相比较,微波辅助合成尾式卟啉化合物明显缩短了反应时间,提高了反应效率。The synthesis of a novel tailed porphyrin（p-BrTMOPP） is studied. The p-HTMOPP was prepared from pyrrole,p-hydroxybenzaldehyde and p-methoxybenzaldehyde in propionic acid solution,and then p-HTMOPP and 1,4-dibromobutane were mixed in DMF solution to synthetize p-BrTMOPP by using microwave-assisted synthesis technology. The target compound, p-BrTMOPP, was characterized by using UV-vis, IR,and ESI-MS spectra. The p-BrTMOPP was prepared from p-HTMOPP and 1,4-dibromobutane in DMF solution at 90℃for 30 min under microwave-assisted with a yield of 89.2%. A tailed porphyrin was synthesized under microwave-assisted,and with less time and higher efficiency compared with the conventional method.

关 键 词：尾式卟啉 微波辅助合成 表征 

分 类 号：TQ062[化学工程]