胸液中IFN-γ对结核性胸膜炎的诊断价值  

Diagnostic value of detection of IFN-γ in pleural effusion to tuberculous pleuritis

作　　者：李志惠[1] 赵杰[1] 崔丹[1] 刘朋冲[1] 

机构地区：[1]河北省胸科医院,河北石家庄050041

出　　处：《临床肺科杂志》2014年第6期1064-1066,共3页Journal of Clinical Pulmonary Medicine

摘　　要：目的探讨利用酶联免疫斑点(Elispot)法检测胸水结核分枝杆菌特异性IFN-γ在诊断结核性胸膜炎的价值。方法对147例结核性胸膜炎患者(结核性胸膜炎组)、69例非结核性胸膜炎患者(对照组)胸水单个核细胞结核菌抗原特异性IFN-γ分泌水平进行检测,对比两者的检测差异。结果结核性胸膜炎组患者胸水IFN-γ水平显著高于对照组(P<0.001)。结论利用酶联免疫斑点技术检测胸液标本结核分枝杆菌特异性IFN-γ可用于结核性胸膜炎的诊断及鉴别诊断。Objective To analyze the diagnostic value of detection of IFN-γ, in pleural effusion to tubercu- lous pleuritis. Methods The level of IFN-γ was detected in 147 patients with tuberculous pleuritis and 69 patients with non-tuberculous pleuritis by Elispot technology. Results The level of IFN-γ, in patients with tuberculous pleuri- tis was significantly higher than that in patients with non-tuberculous pleufitis （ P 〈 0. 001 ）. Conclusion The detec- tion of mycobacterium tuberculosis-specific interferon-gamma in pleural effusion by Enzyme-linked immunospot assay is useful for diagnosis of patients with tuberculous pleuritis.

关 键 词：酶联免疫斑点技术 结核性胸膜炎 Γ干扰素 

分 类 号：R521.7[医药卫生—内科学]