痰热清辅助治疗鲍曼不动杆菌肺部感染的效果观察  

Adjuvant therapeutic effect of tanreqing on pulmonary infection caused by Acinetobacter baumannii

作　　者：刘瑶[1] 马晓俞 陈淑萍[1] 徐航[1] 于湘友[1] 

机构地区：[1]新疆医科大学第一附属医院,新疆乌鲁木齐830054

出　　处：《中国感染控制杂志》2014年第3期134-137,共4页Chinese Journal of Infection Control

基　　金：乌鲁木齐市科学技术项目(Y111310024)

摘　　要：目的探讨痰热清注射液辅助治疗鲍曼不动杆菌肺部感染的效果,为临床更有效地治疗鲍曼不动杆菌引发的肺部感染提供参考。方法选取某院重症监护室2012年1月—2013年3月鲍曼不动杆菌肺部感染患者52例,随机分为常规治疗组(29例)和痰热清辅助治疗组(23例)。常规治疗组按照常规治疗方法治疗(根据病原微生物培养及药敏试验结果确定抗菌药物使用种类);痰热清治疗组在常规治疗的基础上加用痰热清注射液辅助治疗。观察两组疗效。结果痰热清治疗组的急性生理学与慢性健康状况评分系统(APACHEⅡ评分)、序贯器官衰竭评分(SOFA)较常规治疗组下降更明显;其ICU住院天数、28 d抗菌药物使用天数、机械通气天数均明显少于常规治疗组(P<0.05)。两组28 d、90 d病死率差异无统计学意义(P>0.05)。结论痰热清注射液与抗菌药物具有协同抗菌作用,对治疗鲍曼不动杆菌肺部感染具有一定疗效。Objective To evaluate the effect of herbal tanreqing injection on adjuvant therapy for Acinetobacter baumannii （A. baumannii） pulmonary infection, and provide reference for more effective treatment for pulmonary infection caused by A. baumannii. Methods Fifty-two intensive care unit patients with A. baumannii pulmonary in- fection between January 2012 and March 2013 were selected and randomly divided into conventional therapy group （29 cases）and tanreqing adjuvant therapy group（23 cases）. Conventional therapy group were treated with antimicro- bial agents according to pathogenic microbiological culture and antimierobial susceptibility testing results; tanreqing adjuvant therapy group were treated with conventional therapy plus tanreqing injection, therapeutic effect of two groups was compared. Results Acute physiology and chronic health evaluation Ⅱ （APACHE Ⅱ ） score and sequential organ failure assessment （SOFA） score of tanreqing adjuvant therapy group decreased more significantly than the conventional therapy group; the ICU length of stay, antimicrobial days within 28 days, mechanical ventilation days were all significantly lower than conventional therapy group（P（0. 05）. Mortality within 28 and 90 days was not significantly different between two groups（P〉0. 05）. Conclusion Tanreqing injection and antimicrobial agents has a synergistic antimicrobial effect, and has certain therapeutic effect on A. baumannii pulmonary infection.

关 键 词：鲍曼不动杆菌 肺部感染 痰热清 抗感染治疗 中药 

分 类 号：R563.1[医药卫生—呼吸系统]