黄葵胶囊治疗慢性肾炎CKDⅢ期37例  

Clinical Research of Huangkui Capsule in Treating Chronic Kidney Disease Ⅲ Phase of Chronic Nephritis in 37 Cases

作　　者：沈烨渠[1] 廖顺花[1] 孙悦[2] 蒋宇锋 何立群[2,3] 

机构地区：[1]中国人民解放军第一八八医院,广东潮州521000 [2]上海中医药大学附属曙光医院,上海210203 [3]上海市中医临床重点实验室,上海201203

出　　处：《中国实验方剂学杂志》2014年第10期205-208,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(81173219);科技部中医药行业科研专项项目(201007005);高等学校博士学科点专项科研基金项目(20093107110006);上海市科委创新行动计划项目(11DZ1973100);上海市高校创新团队建设项目

摘　　要：目的:探讨黄葵胶囊对湿热型慢性肾炎慢性肾脏病(CKD)Ⅲ期患者的临床疗效。方法:按就诊顺序随机分为两组,最终纳入统计的治疗组37例,对照组36例,对照组针对危险因素等进行一般治疗与营养治疗,治疗组在对照组治疗的基础上加用黄葵胶囊(2.5 g/次,3次/d,饭后30 min口服)治疗,检测治疗前后24 h尿蛋白定量、血肌酐(SCr)、血尿素氮(BUN)、肾小球滤过率(GFR)。结果:黄葵胶囊治疗组能明显改善慢性肾炎CKD3期湿热型患者的临床症状(P<0.05),降低SCr,24 h尿蛋白定量(P<0.05),使GFR有显著的增加(P<0.01),两组治疗后比较统计学有显著性差异。结论:黄葵胶囊能减少蛋白尿,改善肾功能,尤其能明显升高GFR,具有稳定GFR作用。Objective： To investigate the curative effects of Huangkui capsule on dampness-heat of chronic kidney disease （CKD） 3 phase. Method： The patients were randomly divided into conventional western medicine treated group （control group, 36 cases） and conventional western medicine plus Huangkui capsule treated group （treatment group,37 cases）.The serum-creatinine （SCr）,blood urea nitrogen （BUN）,proteinuria （Pro） and glomerular filtration rate （GFR）were examined in 37 cases, compared with conventional medicine treated group with western medicine. Result： Combined treatment of Chinese and western medicine can improve symptoms and decrease SCr,proteinuria,and increase the level of GFR in the patients with dampness-heat of CKD 3 period patients. Conclusion： Huangkui capsule combined with conventional western medicine can reduce proteinuria and improve renal function, can effectively increased significantly the GFR in the patients with CKD 3 period of chronic nephritis.

关 键 词：黄葵胶囊 湿热型 慢性肾炎 慢性肾脏病期 

分 类 号：R287[医药卫生—中药学]