参杞强精胶囊对免疫抑制小鼠免疫功能的影响  

Influences of Shenqi qiangjing Capsule on the Immune Function of Immunosuppressed Mice

作　　者：田元春[1] 张泉[2] 雷崇忠 陆桂丽[1] 

机构地区：[1]广西中医药大学第一附属医院药学部,南宁530023 [2]桂林三金药业股份有限公司,桂林541004

出　　处：《医药导报》2014年第2期176-179,共4页Herald of Medicine

基　　金：广西壮族自治区卫生厅中医药医院制剂类课题(GZYZ-10-05);广西壮族自治区卫生厅中医药科技专项课题(GZYZ1101)

摘　　要：目的观察参杞强精胶囊对环磷酰胺免疫抑制小鼠免疫功能的影响。方法 60只实验小鼠随机分为6组,正常组,模型组,参杞强精胶囊高、中、低剂量组(给予参杞强精1.0,0.5,0.25 g·kg-1)和阳性对照组(给予左旋咪唑0.05 g·kg-1),除空白组外,其他组皮下注射环磷酰胺(50 mg·kg-1)建立免疫抑制小鼠模型。各组连续给药10 d后,检测小鼠外周白细胞数、免疫器官脏器指数、碳粒廓清能力、淋巴细胞转化率、血清溶血素含量。结果参杞强精胶囊各剂量组小鼠的外周白细胞数量、碳粒廓清能力、淋巴细胞转化率、血清溶血素含量均明显提高(P<0.05或P<0.01),与模型组比较差异有统计学意义;高剂量参杞强精胶囊明显提高胸腺和脾脏指数(P<0.05)。结论参杞强精胶囊对免疫抑制小鼠的免疫功能有正调节作用。Objective To observe the immuno-regulatory effect of shenqiqiangjing capsule （ SQQJC） on mice treatedwith cyclophosphamide. Methods Sixty mice were randomly divided into the control group, model group, positive group,SQQJC-high, medium and low dose groups. Except in the control group, all mice were injected with cyclophosophamide （50 mg·kg-1 ）. Mice in the SQQJC鄄high, medium and low dose groups were administered with 1. 0, 0. 5, and 0. 25 mg·kg-1SQQJC, respectively. Mice in the control group were administered with solvent. Mice in the positive group were administered withlevamisole for 10 days. The mice were examined for the total peripheral white blood cells, immune organ weight index, carbonparticle clearance capability of macrophage, the lymphocyte transformation rate and the serum hemolysin content. Results Compared with the model group, the peripheral white blood cells, carbon particle clearance capability of macrophage, thelymphocyte transformation rate and the serum hemolysin content were significantly increased in mice treated with SQQJC at low,medium and high doses （P〈0. 05 or P〈0. 01）; the immune organ weight indexes were significantly increased in mice treatedwith SQQJC at high dose （P〈0. 05）. Conclusion SQQJC can improve the immune function of the immunosuppressed mice.

关 键 词：参杞强精胶囊 免疫功能 环磷酰胺 

分 类 号：R285.5[医药卫生—中药学]