脑钠肽对糖尿病心肌病诊断价值及丹红注射液对其的干预作用分析  

Effect of Danhong Injection on Brain Natriuretic Peptide in Diabetic Cardiomyopathy

作　　者：魏进[1] 韩玉亭[1] 高明殿[1] 

机构地区：[1]山东省昌邑市人民医院

出　　处：《中西医结合心脑血管病杂志》2014年第3期290-291,共2页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

摘　　要：目的探讨血浆脑钠肽(BNP)对糖尿病心肌病(DC)患者的诊断价值,并探讨丹红注射液对糖尿病心肌病患者血浆BNP水平的影响。方法测定42例住院糖尿病心肌病患者血浆BNP值,同时测定心脏彩超各相关参数。分析患者BNP与左室收缩末内径(LVEDs)、左室舒张末内径(LVEDd)、左室射血分数(LVEF)、二尖瓣口舒张早期与舒张晚期血流峰值速度比值(E/A值)等因素的相关性。将42例糖尿病心肌病患者随机分为两组,对照组采用常规治疗,治疗组在常规治疗的基础上加用丹红注射液。治疗前及治疗2周后检测两组BNP水平,进行同组治疗前后比较及组间比较。结果 BNP与LVESd呈负相关(r=-0.679,P=0.000);BNP与LVEDd呈负相关(r=-0.554,P<0.01);BNP与E/A呈负相关(r=-0.468,P=0.002);BNP与LVEF呈负相关(r=-0.478,P=0.001)。治疗2周后,血浆BNP水平均较治疗前降低(P<0.01),但治疗组较对照组血浆BNP水平下降更明显。与对照组比较,治疗组BNP水平明显减低,存在统计学意义(P<0.05)。结论糖尿病心肌病患者血浆BNP水平与LVESD、LVEDD、E/A以及LVEF均有很好的相关性。能较好地反映心脏病患者左室功能状态。丹红注射液可明显降低糖尿病心肌病患者血浆BNP水平,对改善患者的心功能有重要意义。Objective To evaluate the effect of Danhong injection(DHI)on brain natriuretic peptide(BNP)in patients with diabetic cardiomyopathy.Methods Forty-two patients with diabetic cardiomyopathy were randomly divided into two groups:Control group treated by conventional medical treatment,and treatment group treated with conventional treatment and DHI.The plasma BNP levels and UCG parameters were measured.Correlation analysis between plasma concentrations of BNP,left ventricular ejection fraction(LVEF),E/A,left ventricular end-systolic internal diameter(LVEDs),and left ventricular dimension at end diastole(LVEDd)were performed.Results The concentrations of plasma BNP was correlated positively with LVEDs,LVEDd,E/A(r=-0.679,-0.554,-0.468,P<0.001)and correlated negatively with LVEF(r=-0.478,P<0.01).The plasma concentration of BNP in treatment group was lower than that in control group(P<0.05).Conclusion The concentration of plasma BNP might reflect severity of heart failure of diabetic cardiomyopathy.DHI might treat heart failure of diabetic cardiomyopathy,which could improve heart function by decrease the concentration of plasma BNP.

关 键 词：糖尿病心肌病 脑钠肽 心功能 丹红注射液 

分 类 号：R587.2[医药卫生—内分泌]