贝前列腺素钠对早期糖尿病肾病患者尿白蛋白排泄率血清胱抑素C及血管内皮功能的影响  

Effect of the beraprost sodium on serum cystatin C,urinary microalbumin excretion rate and vascular endothelial function in patients with early diabetic nephropathy

作　　者：卢伟波[1] 李舒敏[1] 吕以培[1] 黄中莹[1] 杨丕坚[1] 

机构地区：[1]钦州市第二人民医院内分泌科,广西535000

出　　处：《中国临床新医学》2014年第4期317-320,共4页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

摘　　要：目的探讨贝前列腺素钠对早期糖尿病肾病患者尿白蛋白排泄率、血清胱抑素C及血管内皮功能的影响。方法选择早期糖尿病肾病患者58例,按随机数字表法分为对照组30例和治疗组28例。对照组予低蛋白饮食、人胰岛素控制血糖、控制血压等常规治疗;治疗组在常规治疗的基础上使用贝前列腺素钠40μg,口服3次/d,共使用12周。检测早期糖尿病肾病患者治疗前后糖化血红蛋白(HbA1c)、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、24 h尿白蛋白排泄率(24h UAER)、血清胱抑素C(Cys-C)、内生肌酐清除率(Ccr)、血内皮素-1(ET-1)水平,同时利用超声检测肱动脉血流介导的内皮依赖性血管舒张功能(FMD)。结果两组患者治疗前后血糖、血压、血脂等指标比较差异无统计学意义(P>0.05),治疗组患者治疗后24 h UAER、血清Cys-C、ET-1较对照组显著降低,Ccr、内皮依赖性血管舒张功能(FMD)较对照组显著升高,差异均有统计学意义(P均<0.05)。结论贝前列腺素钠有效地降低早期糖尿病肾病患者的血清Cys-C及24h UAER水平,并改善血管内皮功能。Objective To investigate the effect of the beraprost sodium on serum cystatin C, urinary mi-croalbumin excretion rate and vascular endothelial function in patients with early diabetic nephropathy .Methods Fif-ty-eight patients with early diabetic nephropathy were selected and randomly divided into 2 groups（control group with 30 cases and treatment group with 28 cases）.Control group was treated with insulin,low-protein diet,control blood pressure;the treatment group was treated with beraprost sodium 40 μg tid on the basis of normal treatment for 12 weeks.The endothelium-dependent flow-mediated dilatation（FMD） of brachial artery was determined with ultrasound , and the levels of endothelin-1（ET-1）, Glycated hemoglobin（HbA1c）, triglycerides（TG）, total cholesterol（TC）, high-density lipoprotein cholesterol （ HDL-C） , low density lipoprotein cholesterol （ LDL-C） , 24 h urinary albumin ex-cretion rate（UAER）, serum cystatin C（Cys-C）, endogenous creatinine clearance （Ccr） were measured respectively before and after treatment .Results There was no statistically significant difference of blood sugar ,blood pressure, blood lipid before and after treatment （P〉0.05）.After treatment,the levels of UAER, Cys-c and ET-1 in treatment group were significantly lower than those of the control group （ P〈0.05 ） , the levels of Ccr and FMD in treatment group were increased more significantly than control group （ P〈0.05 ） .Conclusion The beraprost sodium can effec-tively reduce the levels of UAER , Cys-C and recovery renal vascular endothelial function in the patients with early di -abetic nephropathy .

关 键 词：贝前列腺素钠 糖尿病肾病 内皮功能障碍 

分 类 号：R587.2[医药卫生—内分泌]