p33ING1b和p53在银屑病和基底细胞癌中的表达及临床意义  

Expressions and clinical significance of p33ING1b and p53 in psoriasis and basal cell carcinoma

作　　者：贺琪[1] 岳青[1] 皮先明[2] 石全[2] 陈宏翔[1] 李家文[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院皮肤科,武汉市430022 [2]湖北省中医院皮肤科,武汉市430061

出　　处：《实用医学杂志》2014年第9期1391-1394,共4页The Journal of Practical Medicine

基　　金：国家自然科学基金资助项目(编号:30972654;81271765;81171495);湖北省自然科学基金资助项目(编号:2010CDB11001)

摘　　要：目的:探讨肿瘤抑制因子p53和生长抑制因子p33ING1b在人类银屑病和基底细胞癌(basal cell carcinoma,BCC)中的表达情况及临床意义。方法 :采用免疫组织化学Envision方法检测p53和p33ING1b在36例寻常型银屑病皮损(银屑病组)、28例BCC皮损(BCC组)和14例正常表皮(正常对照组)中的蛋白表达。结果:p53在正常对照组、银屑病组和BCC组中表达递增,p33ING1b在3组中表达递减,组间比较差异均有显著性(均P<0.05)。银屑病组和BCC组中,p53与p33ING1b之间均存在显著正相关(均P<0.05)。结论:p53和p33ING1b协同作用于增生性皮肤病的局部皮损,是细胞异常增殖的重要机制之一。Objective To discuss the expressions and clinical significance of p53 and p33INGlb in human psoriasis and basal cell carcinoma （BCC）. Methods Immunohistocbemistry EnVision technique was used to detect the expressions of p53 and p33INGlb in samples of 36 psoriasis vulgaris, 28 BCC and 14 normal skins. Results The expression of p53 increased while p33INGlb had a degressive expression in the control group, the psoriasis group and the BCC group. It was found significant statistical difference between the two groups （all P 〈 0.05 ）. Prominent positive correlation between p53 and p33INGlb were found in both psoriasis group and BCC group （all P 〈 0.05）. Conclusions p53 coacts with p33INGlb at local lesions of abnormal proliferative diseases. It＇s one of the most prominent mechanisms contributing to deviant cell proliferation.

关 键 词：P53 P33ING1B 银屑病 基底细胞癌 ING1 

分 类 号：R758.63[医药卫生—皮肤病学与性病学] R739.5[医药卫生—临床医学]