冠心病患者感染性相关指标变化的临床研究  

Clinical study on changes of related infectious indicators of patients with coronary heart disease

作　　者：叶显华[1] 周亮[1] 杨建敏[1] 童国新[1] 徐鹏[1] 王宁夫[1] 

机构地区：[1]杭州市第一人民医院心内科,浙江杭州310006

出　　处：《中华医院感染学杂志》2014年第9期2197-2199,共3页Chinese Journal of Nosocomiology

基　　金：杭州市卫生局基金资助项目(HW-2009B-10043)

摘　　要：目的探讨研究老年冠心病患者的多项感染性指标变化情况,以期为临床诊断治疗提供参考依据。方法选取2010年1月-2012年12月老年冠心病患者3 160例,从中选取210例感染患者作为观察组,选取同期健康体检的210名老年人作为对照组,对两组的血清白介素10、白介素8、白介素6、肿瘤坏死因子、γ干扰素和高敏C-反应蛋白的水平进行比较。结果观察组患者血清白介素10、8、6、肿瘤坏死因子、γ干扰素和高敏C-反应蛋白水平均比对照组患者高,差异有统计学意义(P<0.05);Ⅳ级患者血清白介素10、8、6、肿瘤坏死因子、γ干扰素和高敏C-反应蛋白水平均比Ⅱ级和Ⅲ级患者高,而Ⅲ级患者6项指标比Ⅱ级患者高,差异有统计学意义(P<0.05);心肌梗死患者血清白介素10、8、6、肿瘤坏死因子、γ干扰素和高敏C-反应蛋白水平均比稳定性心绞痛和不稳定性心绞痛患者高,而不稳定性心绞痛患者6项指标比稳定性心绞痛患者高,差异有统计学意义(P<0.05)。结论老年冠心病患者的血清白介素10、8、6、肿瘤坏死因子、γ干扰素和高敏C-反应蛋白水平均有升高的趋势,不同NYHA分级患者及不同分型患者的感染性指标存在明显差异,对疾病诊断有比较高的价值。OBJECTIVE To explore the changes of multiple infectious indicators of elderly patients with coronary heart disease so as to provide guidance for clinical diagnosis and treatment.METHODS A total of 3 160elderly patients with coronary heart disease,who were treated in the hospital from Jan 2010to Dec 2012,were enrolled in the study,then 210patients with infections were extracted and assigned as the observation group,meanwhile,210 healthy elderly people were recruited as the control group,the levels of the serum interleukin-10,interleukin-8, interleukin-6,tumor necrosis factor.RESULTS The levels of the serum interleukin-10,interleukin-8,interleukin-6,tumor necrosis factor,γinterferon,and high-sensitivity C-reactive protein of the observation group were significantly higher than those of the control group,the differences were significant（P＆lt;0.05）.The levels of the serum interleukin-10,interleukin-8,interleukin-6,tumor necrosis factor,γ-interferon,and high-sensitivity C-reactive protein of theⅣ grade patients were significantly higher those of theⅡ grade patients or theⅢ grade patients, however,the levels of the six indicators of theⅢ grade patients were significantly higher than those of the Ⅱ grade patients,the differences were significant（P＆lt;0.05）.The levels of the serum interleukin-10,interleukin-8, interleukin-6,tumor necrosis factor,γ-interferon,and high-sensitivity C-reactive protein of the patients with myocardial infarction were significantly higher than those of the patients with stable angina pectoris or the patients with unstable angina pectoris,however,the levels of the six indicators of the patients with unstable angina pectoris were significantly higher than those of the patients with stable angina pectoris,the differences were significant（P＆lt;0.05）.CONCLUSION The levels of the serum interleukin-10,interleukin-8,interleukin-6,tumor necrosis factor,γ-interferon,and high-sensitivity C-reactive protein show upward trends among the elderly patients with coronary heart di

关 键 词：老年 冠心病 感染性指标 变化 

分 类 号：R541.4[医药卫生—心血管疾病]