咪达唑仑、异丙酚镇静对颅脑损伤患者垂体前叶激素水平的影响分析  

Affect analysis of midazolam,isopropylphenol sedation on anterior pituitary hormone levels of patients with traumatic brain injury

作　　者：吕刚[1] 

机构地区：[1]山东省日照市人民医院手术室,山东日照276826

出　　处：《中国当代医药》2014年第13期73-74,80,共3页China Modern Medicine

摘　　要：目的 探讨咪达唑仑、异丙酚镇静对颅脑损伤患者垂体前叶激素水平的影响。方法 选择本院2010年6月～2012年10月收治的68例重症颅脑损伤患者，均在镇静下行机械通气治疗，将全部患者随机分为两组。每组各34例，异丙酚组采用异丙酚镇静，咪达唑仑组采用咪达唑仑镇静，镇静治疗1、3d后，抽取静脉血检测两组患者的血清生长激素（GH）、泌乳素（PRL）、促甲状腺激素（TSH）、血清皮质醇（COR）水平，并进行组间比较。结果 镇静治疗1、3d时，异丙酚组TSH高于咪达唑仑组，COR、GH低于咪达唑仑组，两组比较差异有统计学意义（P〈0．05），两组各时间点PRL比较差异无统计学意义（P〉0．05），两组机械通气治疗1周后上述指标差异无统计学意义（P〉0．05）。结论 咪达唑仑、异丙酚用于颅脑损伤患者镇静治疗对垂体前叶激素水平影响均较小，且对预后影响亦无明显差异。均可用于颅脑损伤的镇静治疗。Objective To investigate the affect of midazolam,propofol sedation on anterior pituitary hormone levels of patients with traumatic brain injury. Methods 68 cases of patients with severe head injury from June 2010 to October 2012 were selected and randomly divided into two groups,34 cases in each group,isopropylphenol group patients were given isopropylphenol sedation treatment,midazolam group patients were given midazolam sedation therapy,after 1,3 days of sedation treatment,the level of serum growth hormone （GH）,prolactin （PRL）,thyroid-stimulating hormone （TSH）, serum cortisol （COR） in two groups were detected and compared. Results After 1,3 days of sedation treatment,the TSH of isopropylphenol group was higher than that of midazolam group,the COR,GH were less than that of midazolam group respectively,the difference was statistically significant （P〈0.05）,the PRL of two groups in each time point was not significantly different （P〉0.05）, and above index of two groups showed no significant differences after one week treatment （P〉0.05）. Conclusion Affect of midazolam,isopropylphenol on anterior pituitary hormone levels of patients with traumatic brain injury is not significant,and prognosis of patients is not significantly different,all are worth of application.

关 键 词：咪达唑仑 异丙酚 颅脑损伤 镇静 机械通气 

分 类 号：R614[医药卫生—麻醉学]