骨形态发生蛋白-7与肾剪切波速度在2型糖尿病肾病中的相关性研究  

Clinical implication of bone morphogenetic protein-7 and the kidney shear wave velocity in the diagnosis and treatment of diabetic nephropathy

作　　者：于宁[1] 杨舜舜[1] 费洁[1] 王正滨[2] 杨雪[1] 

机构地区：[1]青岛大学附属医院超声科,266003 [2]青岛大学附属医院黄岛分院超声诊疗科,266003

出　　处：《中华超声影像学杂志》2014年第4期316-319,共4页Chinese Journal of Ultrasonography

基　　金：山东省高等学校科技计划项目（J12LL08）

摘　　要：目的 探讨骨形态发生蛋白-7 （BMP-7）与肾剪切波速度（SWV）在糖尿病肾病中的相关性.方法 将150例糖尿病患者根据尿白蛋白排泄率（UAER）分为3组：正常白蛋白尿（NA）组、微量白蛋白尿（MA）组、临床蛋白尿（CA）组;选择50例健康体检者作为对照组（NC）.检测各组血BMP-7水平,并利用声触诊组织量化技术检测各组肾实质SWV,比较各组间的BMP-7水平及肾实质SWV.对糖尿病肾病各组的血BMP-7水平与SWV进行相关性分析.结果 血BMP-7水平：CA组＜MA组＜NA组（P＜0.05）;SWV测值：CA组＞MA组＞NA组（P＜0.05）.NC组与NA组血BMP-7水平及SWV测值差异均无统计学意义（P＞0.05）.血BMP-7与肾实质SWV之间存在显著负相关（r=-0.612,P＜0.05）.结论 血BMP-7水平会随糖尿病肾病的进展而减低,而肾实质SWV则随糖尿病肾病的进展而升高,并可间接反映血清BMP-7水平,二者在糖尿病肾病诊治中有重要的应用价值.Objective To investigate the value of bone morphogenetic protein-7 （BMP-7） and the kidney shear wave velocity （SWV） in the diagnosis and treatment of diabetic nephropathy.Methods 150 cases of patients with diabetic mellitus were divided into three groups according to 24h urinary albumin excretion （Ualb）：normalbuminuria （NA） group,microalbuminuria （MA） group and clinical proteinuria （CA） group;50 healthy subjects were selected as the control group （NC）.The levels of blood BMP-7 were detected and the virtual touch tissue quantification （VTQ） was used to detect renal SWV in four groups.Both the BMP-7 level and the renal parenchyma SWV were compared among four groups.Then correlation analysis was made between blood of BMP-7 level and renal SWV in diabetic nephropathy groups.Results Blood BMP-7 level：the lowest was CA group,the middle one was MA group,and the highest was NA group （P 〈0.05）,the NC group and the NA group had no significant difference （P 〉0.05）; SWV measured values：CA group was the highest,MA group was middle one and the NA group was the lowest （P 〈 0.05）,the difference between NC group and the NA group was not significant statistically （P 〉0.05）.The blood levels of BMP-7 and renal SWV had a significant negative correlation （r =-0.612,P 〈0.05）.Conclusions The blood BMP-7 levels downregulate with the progressing of diabetic nephropathy,but the renal SWV increases with the diabetic nephropathy deterioration,and may indirectly reflects blood BMP-7 levels.Both of them have important application values in the diagnosis or treatment of diabetic nephropathy.

关 键 词：弹性成像技术 糖尿病肾病 剪切波速度 骨形态发生蛋白质7 

分 类 号：R587.2[医药卫生—内分泌]