肾组织内特殊有形结构形成的肾脏病的电镜诊断  

Electron microscopic diagnosis of renal diseases with specific organized deposits

作　　者：王素霞[1] 柴立军[1] 谢燕玲[1] 王书合[1] 

机构地区：[1]北京大学第一医院电镜室,北京100034

出　　处：《电子显微学报》2014年第2期163-167,共5页Journal of Chinese Electron Microscopy Society

摘　　要：本研究对我院电镜室收集的12,332例肾活检标本进行透射电镜观察,对超微结构表现特殊有形结构或形成特殊形态沉积的肾脏病进行超微病理特点分析,根据电镜在其病理诊断中的作用分为三类:分别为决定性诊断作用、重要诊断价值和辅助参考作用。结果显示,肾组织内特殊有形结构形成的肾脏病占肾活检病例的1.65%,其中,以淀粉样变为最常见,其次为冷球蛋白血症肾损害。电镜检查对于大多数超微结构表现特殊有形结构的肾脏病的诊断具有重要诊断价值;尤其是对于早期淀粉样变、纤维样和免疫触须样肾小球病、致密物沉积病和Fabry氏病的诊断具有决定性诊断作用。A total of 12332 cases of renal biopsies collected from Peking University First Hospital from 1995 to 2006 were studied by transmission electron microscopy （EM）. 203 cases of them （ 1.65% ） were found to have specific organized deposits ultrastructurally. The most common disease was renal amyloidosis, and the followed one was cryoglobulinemia related glomerulonephritis. The roles of EM in the diagnosis of renal diseases were divided into three groups： crucial role, important contribution, and auxiliary contribution. EM made an important contribution to the diagnosis of the majority of renal diseases with organized deposits, and it played a crucial role in the diagnosis of early amyloidosis, fibrillary and immunotactoid glomerulopathy, dense deposit disease, and Fabry disease.

关 键 词：肾脏病 透射电镜 特殊有形结构 超微病理 

分 类 号：R692[医药卫生—泌尿科学] R361.3[医药卫生—外科学]