二十二碳六烯酸和卵磷脂联合用药对小鼠睡眠的影响  

The Effects of Combining DHA with Lecithin on Mouse Sleep

作　　者：周洪盼 赵廷坤[1] 韩海林[1] 王玉明[2] 薛长湖[2] 曲梅花[1] 戴功[1] 

机构地区：[1]潍坊医学院药理学教研室,山东潍坊261053 [2]中国海洋大学食品科学与工程学院

出　　处：《潍坊医学院学报》2014年第2期143-146,共4页Acta Academiae Medicinae Weifang

基　　金："十二五"国家科技支撑计划(No.2012BAD33B07);国家教育部留学回国人员科研启动金(2011年第43批);山东省自然基金(ZR2009DM024;ZR2011HM043;ZR2009CL047);山东省教育厅基金(J11LF33)

摘　　要：目的观察二十二碳六烯酸(DHA)和卵磷脂(Lecithin)联合用药对小鼠睡眠的影响。方法通过测定小鼠直接睡眠时间、戊巴比妥钠诱导的睡眠时间、阈下剂量的睡眠发生率及巴比妥钠诱导的睡眠潜伏时间,观察DHA鱼油和卵磷脂联合用药对小鼠睡眠的改善作用。结果各剂量组小鼠体重增长无差异,无直接睡眠作用。DHA鱼油能够缩短巴比妥钠诱导的小鼠睡眠潜伏期(P<0.05)。DHA鱼油和卵磷脂联合用药能够增加戊巴比妥钠阈下剂量的睡眠发生率(P<0.05),缩短巴比妥钠诱导的小鼠睡眠潜伏期(P<0.05)。结论 DHA鱼油和卵磷脂联合用药能够改善小鼠的睡眠。Objective To study the sleep improvement function of DHA ＋Lecithin.Methods By measur-ing the direct sleep time ,the sleep time that induced by pentobarbital sodium ,the sleep incidence rate of sudbissociative dose and the latency time that induced by barbital sodium ,it could observe the mice sleep improvement function .Results Each dose group had no significant difference on the mice weight and direct inducing sleep .DHA could shorten the la-tency time that induced by barbital sodium （P〈0.05）.DHA＋Lecithin could increase the sleep incidence rate of sud-bissociative dose（P〈0.05） and shorten the latency time that induced by barbital sodium （P〉0.05）.Conclusion DHA＋Lecithin can improve the mice sleep time .

关 键 词：二十二碳六烯酸(DHA) 卵磷脂(Lecithin) 小鼠 睡眠 

分 类 号：R961[医药卫生—药理学]