臭氧与曲安奈德治疗膝关节半月板损伤的病例对照研究  

Case control study on therapeutic effects of ozone and triamcinolone acetonide on the treatment of meniscal injury

作　　者：王兵[1] 董桂芝[1] 鞠衍馨[1] 燕春山[1] 

机构地区：[1]解放军第404医院,山东威海264200

出　　处：《中国骨伤》2014年第4期295-298,共4页China Journal of Orthopaedics and Traumatology

摘　　要：目的：比较曲安奈德、臭氧以及两者联合治疗轻型半月板损伤的临床疗效.方法：2008年1月至2012年12月将MRI诊断为Ⅰ、Ⅱ级的半月板损伤患者119例,分为曲安奈德组、臭氧组和曲安奈德加臭氧联合组.曲安奈德组（A组）40例,男38例,女2例;年龄18～48岁,平均（25.34±6.34）岁;单膝36例,双膝4例;关节积液44膝.臭氧组（B组）39例,男37例,女2例;年龄19～50岁,平均（26.98±7.20）岁;单膝33例,双膝6例;关节积液40膝.曲安奈德加臭氧联合组（C组）40例,男37例,女3例;年龄18～47岁,平均（26.44±6.38）岁;单膝33例,双膝7例;关节积液39膝.3组分别以醋酸曲安奈德3 mg、浓度30 μg/ml的医用臭氧30 ml、两者联合行膝关节腔注射,每周1次,4次为1个疗程.治疗前与治疗后的1个月分别进行Lysholm膝关节功能评分和行MRI检查观察膝关节积液变化并比较.结果：3组治疗前后膝关节功能评分分别为A组：35.68±4.15和65.55±7.66;B组：36.35±6.83和74.39±8.47;C组：36.62±6.03和95.47±4.78.3组治疗后膝关节评分均高于治疗前,C组较A、B组评分高,而A、B组间差异无统计学意义.治疗前MRI检查所见关节积液征象的膝数,A组44膝,B组40膝,C组39膝;治疗后MRI检查所见关节积液征象的膝数,A组14膝,B组15膝,C组5膝.C组消除关节积液的效果优于A、B组,A组和B组间差异无统计学意义.结论：臭氧和曲安奈德治疗轻度半月板损伤对缓解症状、促进关节功能恢复、消退关节积液均有效果,两者联用,效果更佳.To compare the clinical therapeutic effects between ozone and triamcinolone acetonide for the treatment of mild meniseal injury. Methods： From January 2008 to December 2012,119 patients with meniscal injury diagnosed as type I or II by MRI were divided into three groups. In the triamcinolone aeetonide （A） group, there were 38 males and 2 females,with an average age of （25.34±6.34） years old, ranging from 18 to 48 years old; 36 patients had single knee injuries ,4 patients had double knee injuries and 44 knees with joint effusion. In the ozone （B） group ,there were 37 males and 2 females,with an average age of （26.98±7.20） years old, ranging from 19 to 50 years old; 33 patients had single knee injuries, 6 patiens had double knees injuries and 40 knees with joint effusion. In the combination of ozone and triamcinolone acetonide （C） group, there were 37 males and 3 females, with an average age of （26.44±6.38） years old, ranging from 18 to 47 years old; 33 patients had single knee injuries ,7 patients had double knees injuries and 39 knees with joint effusion. The patients were treated with injection of 3 mg triameinolone acetonide alone, 30 ml （30 txg/ml） ozone alone, or both two drugs respectively in knee joint cavity. All the treatment methods were carried out weekly and 4 times injections were required for a treatment course. Knee joint function was evaluated by Lysholm scale and knee joint effusion was examined by MRI before and after treatment. Results： The scale of knee joint function was 35.68±4.15 and 65.55±7.66 in group A, 36.35±6.83 and 74.39±8.47 in group B, 36.62±6.03 and 95.47±4.78 in group C before and after treatment. Compared with that before treatment, the total scale of knee joint function improved after treatment in every group. The total scale of group C was better than that of the other groups after the treatment, but there was no significant difference between group A and group B. The effective rate of these drugson joint effusion was 68.18% in group A,6

关 键 词：臭氧 激素 膝关节 半月板 创伤和损伤 病例对照研究 

分 类 号：R684[医药卫生—骨科学]