SURFACE STRESS PROPERTIES OF DNA-MICROCANTILEVER SYSTEMS  

作　　者：Zouqing Tan Nenghui Zhang Jingjing Li 

机构地区：[1]Shanghai Key Laboratory of Mechanics in Energy Engineering, Shanghai Institute of Applied Mathematics and Mechanics, Shanghai University [2]Department of Mechanics, College of Sciences, Shanghai University

出　　处：《Acta Mechanica Solida Sinica》2014年第2期122-128,共7页固体力学学报（英文版）

基　　金：Project supported by the Natural Science Foundation of China(Nos.10872121 and 11272193);the Research Innovation Program of Shanghai Education Commission(No.09YZ07);the Systems Biology Research Foundation of Shanghai University;the Shanghai Leading Academic Discipline Project(No.S30106)

摘　　要：For the first time, the connection between surface stress and nanoscopic interac- tions of DNA adsorbed on microcantilever is established by combining Strey＇s mesoscopic liquid crystal theory and Stoney＇s formula. It is shown that surface stress depends not only on biomolec- ular interactions of DNA biofilm but also on mechanical properties of cantilever. Considering the correlativity between grafting density and chain length of DNA chain, we discuss the differences between DNA-microcantilever system and DNA solution system. The major theoretical achieve- ment of this model is to identify the main contributions to surface stress under different detection conditions. This provides guidelines for designing new biosensors with high sensitivity and improved reliability.For the first time, the connection between surface stress and nanoscopic interac- tions of DNA adsorbed on microcantilever is established by combining Strey＇s mesoscopic liquid crystal theory and Stoney＇s formula. It is shown that surface stress depends not only on biomolec- ular interactions of DNA biofilm but also on mechanical properties of cantilever. Considering the correlativity between grafting density and chain length of DNA chain, we discuss the differences between DNA-microcantilever system and DNA solution system. The major theoretical achieve- ment of this model is to identify the main contributions to surface stress under different detection conditions. This provides guidelines for designing new biosensors with high sensitivity and improved reliability.

关 键 词：surface stress DNA hybridization microcantilever biosensor energy method biomolecular interaction 

分 类 号：TP212.3[自动化与计算机技术—检测技术与自动化装置]