2型糖尿病患者血浆同型半胱氨酸水平与下肢动脉硬化的关系  

Relationship of plasma homocysteine and lower-extremity atherosclerosis in patients with type 2 diabetes mellitus

作　　者：郭琳[1] 赵宝国 王敏楠[1] 李强[1] 

机构地区：[1]哈尔滨医科大学附属第二医院内分泌代谢病科哈尔滨医科大学激素与内分泌疾病重点实验室,150080 [2]黑龙江省尚志市中元医院急诊内科

出　　处：《临床内科杂志》2014年第4期250-252,共3页Journal of Clinical Internal Medicine

基　　金：黑龙江省科技攻关课题（GA07C303107）

摘　　要：目的 探讨血浆同型半胱氨酸（Hcy）水平与2型糖尿病（T2DM）患者下肢动脉硬化的关系,并分析影响2型糖尿病患者Hcy代谢的因素.方法 将118例2型糖尿病患者分为2组：无下肢动脉硬化并发症组（55例）和2型糖尿病合并下肢动脉硬化病变组（63例）;60例体检正常者作为正常对照组.采用酶联免疫吸附法（ELISA）测定血浆Hcy浓度,发光免疫法测定叶酸、VitB12浓度;自动生化分析仪测定空腹血糖（FBS）、总胆固醇（TC）、三酰甘油（TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、糖化血红蛋白（HbA1c）.对各组不同指标的差异进行统计学分析.结果 2型糖尿病合并下肢动脉硬化组患者血浆Hcy浓度较2型糖尿病无下肢动脉硬化组和对照组高,差异有统计学意义（P＜0.05）,血浆Hcy水平与叶酸、VitB12水平呈负相关.结论 Hcy参与了2型糖尿病下肢动脉硬化病变的发病过程,Hcy水平与叶酸、VitB12水平有关.Objective To investigate the relationship of the plasma homocysteine（Hcy） level and lower-extremity atherosclerosis in patients with type 2 diabetesm mellitus（T2DM）.Methods 118 patients with T2DM were divided into two groups：of whom 63 presented with lower-extremity atherosclerosis were allocated to group DC and 55 patients without lower-extremity atherosclerosis were allocated to group NDC.Sixty health subjects were selected and allocated to control group （group CTR）.The plasma Hcy concentration was determined by ELISA.The clinical and bio-chemical data were compared among all three groups.Results Group DC had higher level of plasma Hcy compared to group NDC and group CTR （P ＜ 0.05 respectively）.Moreover,the level of plasma Hcy was negatively correlated with plasma FA and VitB12 concentrations in group DC.Conclusion Hcy is associated with lower-extremity atherosclerosis in T2DM and the plasma Hcy level may be negatively correlated with FA and VitB12.

关 键 词：2型糖尿病 同型半胱氨酸 下肢血管病变 

分 类 号：R587.1[医药卫生—内分泌]