Chemical constituents from Xiaoaiping injection  

消癌平化学成分研究(英文)

作　　者：王艺润 赵明波[2] 唐丽[1] 屠鹏飞[2] 

机构地区：[1]中央民族大学生命与环境科学学院,北京100081 [2]北京大学医学部药学院天然药物及仿生药物国家重点实验室,北京100191

出　　处：《Journal of Chinese Pharmaceutical Sciences》2014年第4期251-255,共5页中国药学（英文版）

摘　　要：Xiaoaiping injection is a single-prescription of Marsdenia tenacissima. One new compound, tenacigenoside L （1）, along with ten known compounds were isolated from the CHCl3-soluble fraction of Xiaoaiping injection extract by silica gel, ODS, Sephadex LH-20 and semi-preparative HPLC chromatography. The new compound was characterized as 3-O-β-D-oleandropyranosyl- 17β-tenacigenin B. The ten known compounds were identified as tenacigenin B （2）, 17β-tenacigenin B （3）, marsdenoside F （4）, tenacissoside G （5）, tenacissoside I （6）, tenacissoside H （7）, marsdenoside D （8）, tenacigenin A （9）, marsdenoside I （10）, and tenacigenin C （11）. The structures of 11 compounds were elucidated on the basis of extensive analyses of spectroscopic data including MS, 1D NMR and 2D NMR, and comparison of their spectroscopic data with those reported in the literatures.消癌平注射液是通关藤提取物的单方制剂。本研究运用溶剂法结合硅胶、Sephadex LH20、ODS和半制备高效液相色谱等色谱分离方法,从消癌平注射液中间体的氯仿提取物中分离得到11个化合物,通过综合分析MS、1D NMR和2D NMR等光谱数据,11个化合物的结构分别鉴定为:3OβDoleandropyranosyl17βtenacigenin B(1),tenacigenin B(2),17βtenacigenin B(3),marsdenoside F(4),tenacissoside G(5),tenacissoside I(6),tenacissoside H(7),marsdenoside D(8),tenacigenin A(9),marsdenoside I(10)和tenacigenin C(11),其中化合物1为新化合物。

关 键 词：Xiaoaiping injection Marsdenia tenacissima Polyoxypregnane glycoside 

分 类 号：R284[医药卫生—中药学]