万古霉素和去甲万古霉素应用于神经外科病例的回顾分析  

Clinical applications of vancomycin and norvancomycin in hospitalized neurosurgical patients

作　　者：欧阳华[1] 杨帆[1] 黄镇健 

机构地区：[1]厦门大学附属中山医院药学部,361004

出　　处：《中华全科医师杂志》2014年第5期391-393,共3页Chinese Journal of General Practitioners

摘　　要：对本院神经外科使用过万古霉素和去甲万古霉素药物的108份患者病历做回顾性分析。用药目的中用于治疗占78.7％（85/108），预防占21.3％（23/108）；病原学检查送检率88.9％（96例）；去甲万古霉素与万古霉素药物利用指数分别为0.95和0.92；联合用药比例86.1％，最多联合3种抗生素；疑似不良反应发生率6.5％。说明对这两种药物的应用基本合理。The medical records of 108 inpatients treated with vancomycin and norvancomycinin were collected and analyzed retrospectively.And 78.7% of all cases were used for therapy and 21.3% for prevention.The pathologic examination submission rate was 88.9% （ n=96 ）.The drug utilization index （ DUI） of norvancomycin was 0.95 and vancomycin 0.92.The proportion of combination use was 86.1%and a maximum of 3 antibiotics were used.There were 6.5% cases of doubtful adverse drug reaction.The inpatient uses of vancomycin and norvancomycin are basically rational.Indications should be mastered strictly.Empirical and prophylactic uses should be minimized to prevent and delay drug resistance strain from spreading and prolong effectiveness.Necessary therapeutic drug monitoring is required.

关 键 词：万古霉素 去甲万古霉素 合理用药 

分 类 号：R651[医药卫生—外科学]