线虫脂肪模型研究  

Research on Caenorhabditis elegans as model for obesity

作　　者：徐蔓玲 赵阳[2] 贾熙华[2] 季宇彬[1] 

机构地区：[1]哈尔滨商业大学生命科学与环境科学研究中心,哈尔滨150076 [2]北京大学医学部天然药物与仿生药物国家重点实验室,北京100083

出　　处：《哈尔滨商业大学学报（自然科学版）》2014年第2期129-132,共4页Journal of Harbin University of Commerce：Natural Sciences Edition

基　　金：国家863计划项目(2006AA09Z446)

摘　　要：肥胖是一种脂肪酸积累增加的慢性疾病,采用研究模式生物的方法可以有助于探明肥胖产生的致病基因或致病相关因子,进而寻找可能的药物靶点.综述了国内外对线虫脂肪模型的研究进展,分析了线虫体内脂肪酸代谢途径的关键基因和核心通路.线虫脂肪代谢调节研究工作对人类肥胖症等代谢疾病的研究具有重要的提示作用,利用线虫脂肪模型研究降脂减肥药物具有广阔的应用前景.Obesity is a kind of chronic disease with the fatty acid accumulation increased . Studying on the model of organism can discover the obesity disease -causing genes or related pathogenic factors , and find potential drug targets .The progress of research on Caenorhabdi-tis elegans as a model for fatty was summarized in this paper .The key genes and core path-ways in fatty acid metabolism was involved .The data obtained in Caenorhabditis elegans on fatty storage control will contribute largely to the study on metabolism related diseases , such as obesity in human beings .C.elegans may be invaluable in the development of reducing fat and body weightdrugs in the future .

关 键 词：秀丽隐杆线虫 脂肪酸代谢 肥胖 

分 类 号：R285[医药卫生—中药学]