中药植物雌激素双向调节的机制研究  

Study on two-way adjustment mechanism of traditional Chinese medicine phytoestrogens

作　　者：陈嫱[1,2] 李文兰[1,2] 丁振铎[3] 张进进[1] 高尚[1] 李静怡[1] 

机构地区：[1]哈尔滨商业大学生命科学与环境科学研究中心,哈尔滨150076 [2]国家教育部抗肿瘤天然药物工程研究中心,哈尔滨150076 [3]黑龙江生态工程职业学院,哈尔滨150025

出　　处：《哈尔滨商业大学学报（自然科学版）》2014年第2期138-141,153,共5页Journal of Harbin University of Commerce：Natural Sciences Edition

基　　金：哈尔滨商业大学研究生创新科研项目(YJSCX2012-226HSD);国家自然科学基金项目(81073015);哈尔滨市科技创新人才研究专项资金项目(2011RFXXS069)

摘　　要：近年来由于合成类雌激素在治疗中副作用明显,中药植物雌激素在一些雌激素(过多或缺乏)相关疾病的治疗中带来了积极的效果.这类中药具有双向调节的"扶正"作用,故其作用机制研究也广泛的开展起来.主要包括与雌激素核受体的相互作用、对雌激素合成相关酶的调控、影响膜受体途径等.通过查阅相关文献,总结了植物雌激素双向作用机制及其研究的思路和方法,以期为临床上植物雌激素的应用以及其作为保健品的开发提供可靠的借鉴及依据.Recently , the side-effects of the synthetic estrogenic hormone in treatment are found evidently .The application of traditional Chinese medicine phytoestrogen in the related diseases （ overabundance or deficiency ） treatment has acquired positive supports and results . This kind of traditional Chinese medicine has a two-direction “strengthening the body resist-ance” function ,thus there are more researches on its mechanism of action .The researches of this area mainly include the interaction of the estrogenic hormone and hormone receptor , the enzyme ’ s affect in the estrogenic hormone ’ s synthesis and the avenue to the membrane re-ceptor.This paper summarized the related researches in the area of the mechanism of phy-toestrogen’s two-direction effect.And expect to offer experiential and theoretical basis to the clinical application of the phytoestrogen and the exploit of health products .

关 键 词：植物雌激素 雌激素受体 双向调节机制 

分 类 号：R285[医药卫生—中药学]