运动疲劳对大鼠黑质网状部小清蛋白表达的影响  

Effects of Exercise Induced Fatigue on the Expression of the Substantia Nigra Pars Reticulata Parvalbumin in Rats

作　　者：孙丽娜[1] 

机构地区：[1]太原理工大学体育学院,山西太原030024

出　　处：《体育科技文献通报》2014年第6期126-127,共2页Bulletin of Sport Science & Technology

摘　　要：目的:观察运动疲劳及恢复阶段大鼠黑质网状部(substantia nigra pars reticulata,SNr)小清蛋白(Parvalbumin,PV)表达水平的变化,探讨其在运动疲劳中枢调控中的作用。方法:雄性SD大鼠随机分为对照组和运动组,采用免疫组织化学方法观察7天反复力竭跑台运动后即刻、24h和48h SNr内PV的表达变化情况。结果:PV阳性细胞和纤维集中分布于SNr外侧约2/3的区域,SNr内PV表达水平在短期内显著下降(P<0.01),恢复24h后明显回升(P<0.01),并随着恢复时间的延长逐渐达到对照组水平(P>0.05)。结论:运动疲劳可导致SNr内PV表达水平短时间内显著性的下降,同时PV阳性表达集中分布于SNr的外侧区,此区域与SNr接收纹状体腹外侧区神经投射区域相一致,是参与基地神经节运动调控的重要脑区。Objective：To observe the sports fatigue and recovery phase in the rat substantia nigra mesh division （ the substantia nigra pars reticulata , SNr） Parvalbumin （ PV） the change of expression level , discusses its role in the sports fatigue central control .Methods：male SD rats were randomly divided into control group and exercise group, using immunohistochemical method to observe 7 days repeatedly run immediately after exercise , exhaustion of PV within 24 h and 48 h SNr expression changes .Positive results：PV cells and fiber concentration distribution in SNr lateral, about two-thirds of the area within the SNr PV expression level decreased significantly in a short time （P ＆lt;0.01）, and recovery after 24 h rebounded significantly （P ＆lt;0.01）, and gradually with the extension of recovery time up to the level of the control group （P ＆gt;0.05）.Conclusion：exercise fatigue can lead to SNr in PV expression level in a short period of time significant decline , at the same time PV positive expression on the SNr of the lateral distribution area , the area with SNr ventrolateral area receives the striatum neural projection area is consistent , is one of the important brain areas involved in the basal ganglia movement control .

关 键 词：运动疲劳 Γ-氨基丁酸 

分 类 号：G804[文化科学—运动人体科学]