血清Th1/Th2及HSP与急性心肌梗死的关系  

Relationship between serum levels of Th1/Th2 and HSP in acute myocardial infraction

作　　者：贺明轶[1] 秦俭[1] 李俊芬[1] 王征[1] 王涛[1] 翟文亮[1] 

机构地区：[1]首都医科大学宣武医院急诊科,北京100053

出　　处：《海南医学院学报》2014年第6期740-743,共4页Journal of Hainan Medical University

基　　金：北京市卫生局基金(ws201872)~~

摘　　要：目的:探讨血清中辅助性T细胞1(Th1)和Th2及热休克蛋白(HSP)与急性心肌梗死(AMI)的关系。方法:选取来我院就诊的急性心肌梗死患者20例,为AMI组;选取同时间不稳定心绞痛(UA)患者20例为UA组和造影正常的心痛患者20例(对照组)作为观察对象,比较3组外周血及冠脉血中Th1/Th2含量及相应的细胞因子γ干扰素(IFN-γ)、白介素-4(IL-4)浓度;比较不同组间血清中HSP及其抗体含量差异。结果:AMI患者外周血中Th1、Th2及IFN-γ含量、Th1/Th2和IFN-γ/IL-4比值均明显高于UA组和对照组,IL-4含量则明显低于UA组和对照组;AMI患者冠脉阻塞段血清中Th1、Th2及IFN-γ、IL-4含量、Th1/Th2和IFN-γ/IL-4比值均明显高于UA组和对照组;与正常对照组比较,UA组外周血和冠脉血中Th1及IFN-γ含量、Th1/Th2和IFN-γ/IL-4比值明显上升,Th2及IL-4明显下降,差异均具有统计学意义(P<0.05);AMI患者外周血及冠脉阻塞段血清中HSP60及其抗体含量明显高于UA组和对照组;UA组患者外周血和冠脉血中HSP60及其抗体含量明显高于对照组,差异具有统计学意义(P<0.05)。结论:AMI患者发生T细胞亚群偏移现象,主要表现为Th1亢进,HSP60及其抗体表达上升。Objective： To explore the relationship of the serum levels of Th1/Th2 and HSP in acute myocardial infraction. Methods.20 cases patients with acute myocardial infraction admitted to our hospital from July 2012 to December 2013 were selected as AMI group, 20 patients with unstable angina were selected as UA group, and 20 cases patients with angina but were angiographically normal were selected as control group. Then the serum levels of Th1/Th2, IFN-γ,IL-4 and HSP and its antibody in peripheral and coronary blood of three groups were compared. Results：The serum levels of Th1/Th2,IFN-γ and the ratio of Th1/Th2 and IFN-γ/IL-4 of AMI group in peripheral blood were all higher than those of UA group andcontrol group, but the IL-4 concentration was lower than the latter two groups. The serum levels of Th1. Th2.IFN-γ .IL-4 and the ratio of Th1/Th2 and IFN-γ/IL-4 p in coronary blood of AMI group were all higher than that of UA group and control group. Compared with control group, the serum levels of Th1, IFN-7 and the ratio of Th1/Th2 and IFN-γ/IL-4 in peripheral and coronary blood of UA group were significantly increased, but Th2 and IL-4 were significantly decreased （P all〈 0. 05）. The serum levels of HSP60 and its antibody in peripheral and coronary blood of AMI group were all higher than that of UA group and control group, and these parameter of UA group were all higher than that of control group （P all〈0.05）. Conclusion：T-cell subsets offset phenomenon occur in AMI patients, which mainly presented as Th1 hyperactivity, and increased HSP60 and its antibody expression.

关 键 词：急性心肌梗死 辅助性T细胞(TW) 热休克蛋白(HSP) 

分 类 号：R542.22[医药卫生—心血管疾病]