过敏性紫癜患者血中sP-选择素、血管假性血友病因子和可溶性细胞间黏附分子1的检测及意义  

Inspection and value of sP-selection,von Willebrand Factor and soluble intercellular adhesion molecule 1 in allergic Henoch-Schonlein purpura

作　　者：王婷 王静[2] 李强[3] 

机构地区：[1]辽河油田总医院血液内科,辽宁盘锦124010 [2]中国人民解放军总医院健康医学中心特需病房,北京100853 [3]葫芦岛市中心医院血液内科,辽宁葫芦岛125000

出　　处：《海南医学院学报》2014年第6期798-801,共4页Journal of Hainan Medical University

基　　金：辽宁省教育厅资助项目(2009S151)~~

摘　　要：目的:研究过敏性紫癜(HSP)患者血中sP-选择素、血管假性血友病因子(vWF)和可溶性细胞间黏附分子1(sICAM-1)水平的变化,探讨其在HSP发病机制中的作用及临床意义。方法:酶联免疫吸附法(ELISA)检测观察组108例HSP患者血清sICAM-1、血浆sP-选择素和vWF,并与对照组30例健康志愿者对照;比较不同分型HSP患者上述指标的差异。结果:观察组血中sP-选择素、vWF和sICAM-1明显高于对照组,差异有统计学意义(P<0.05);108例HSP患者中,肾型组vWF明显高于非肾型组,差异有统计学意义(P<0.05);其他分型组间比较,差异均无统计学意义(P>0.05)。结论:HSP患者血浆sP-选择素、vWF以及血清sICAM-1的高表达,一定程度上反应了患者血小板活化程度和血管内皮受损程度,是HSP两个重要发病机制。vWF能够一定程度反映脏器受损程度。Objective. To observe changes of blood sP-seleetion, yon Willebrand Factor, Soluble intercellular adhesion molecule 1 in allergic purpura （HSP） patients and to explore the role of the HSP in the pathogenesis of HSP as well as its elinical significance. Methods： Method of enzyme-linked immunosorbent （ELISA） was used to detect serum slCAM 1, sP - selection and vWF of 108 HSP patients in the observation group, and the results were compared with 30 volunteers in the control group. Results： The blood sP-selection, vWF and slCAM 1 of the observation group were significantly higher than those of the control group （P〈0.05） ; Among the 108 patients with HSP, patients with renal type had a significant higher vWF than that of non-renal group （P〈0.05）; no significant difference was found between other type pf HSP patients （P〉0.05）. Oonclusion： Increased expression levels of HSP plasma sP-selection element, vWF and sICAM 1 reflect the degree of platelet activation and endothelial damage, which are two major Dathogenesis of HSP occurrence. VWF can reflect the viscera damages to some extent.

关 键 词：过敏性紫癜(HSP) SP-选择素 血管假性血友病因子(vWF) 可溶性细胞间黏附分子1(sICAM-1) 

分 类 号：R554.6[医药卫生—血液循环系统疾病]