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机构地区:[1]北京市第六医院ICU,100007 [2]北京市第六医院呼吸内科,100007
出 处:《中国全科医学》2014年第11期1311-1313,共3页Chinese General Practice
摘 要:目的探讨肺功能检测中用力肺活量(FVC)替代指标的选择。方法选择2011年1月—2012年10月于我院呼吸内科就诊的稳定期慢性阻塞性肺疾病(COPD)患者304例,其中男197例,女107例;平均年龄(64.7±13.5)岁。对所有患者进行常规肺通气功能检测,测量指标包括FVC、第1秒用力呼气容积(FEV1)、第2秒用力呼气容积(FEV2)、第3秒用力呼气容积(FEV3)、第4秒用力呼气容积(FEV4)、第5秒用力呼气容积(FEV5)、第6秒用力呼气容积(FEV6)、第7秒用力呼气容积(FEV7)、第8秒用力呼气容积(FEV8)及第9秒用力呼气容积(FEV9),并分析用力呼气容积(FEV)与FVC的相关性。结果 304例患者均完成肺通气功能检测,其中肺功能Ⅱ级患者157例(51.6%),Ⅲ级患者124例(40.8%),Ⅳ级患者23例(7.6%),无肺功能Ⅰ级患者。所有患者呼气平均时间为(6.7±3.1)s;观察容积-时间曲线发现有193例(63.5%)患者呼气相能达到平台期;111例(36.5%)患者呼吸相没有出现平台期,其年龄均>65岁;其中肺功能Ⅱ级15例(4.9%),Ⅲ级75例(24.7%),Ⅳ级21例(6.9%)。患者呼气时间测定结果显示,77.6%(236/304)的患者呼气时间>6 s,而>7 s的患者仅占36.8%(112/304)。相关性分析显示,仅FEV6与FVC呈正相关(r=0.357,P=0.047);而FEV2、FEV3、FEV4、FEV5与FVC均无线性相关性(P>0.05)。结论年龄大、肺功能差的COPD患者测定FVC时难以达到平台期,对于呼气相不能达到平台期而未能有效完成FVC的患者,可以考虑FEV6作为FVC的替代指标。Objective To look for alternate index of forced vital capacity. Methods Pulmonary ventilatory function was conducted in 304 patients with stahle chronic obstructive lung disease from January 2011 to October 2012. 197 cases of male and female 107 cases; average age (64. 7 ± 13. 5) years old. Measure including FVC, 1 second forced expiratory volume (FEV1), 2 second forced expiratory volume (FEV2) , 3 second forced expiratory volume (FEV3) , 4 second forced expiratory volume (FEV 4), 5 second forced expiratory volume (FEV 5) and forced expiratory volume in six seconds (FEV 6 ), 7 second forced expiratory volume (FEV7), 8 second forced expiratory volume (FEV8), 9 second forced expiratory volume (FEVg). Analysis of Correlation between expiratory volume (FEV) and FVC. Results All patients were complete lung ventilation function index detection, including Ⅱ grade 157 cases of patients with lung function (51. 6% ),Ⅲ grade 124 patients (40. 8% ) , Ⅳ grade 23 patients (7. 6% ), no pulmonary function in patients with stage Ⅰ. All patients exhale average time of (6. 7 ± 3. 1) s, observed volume - time curves found in 193 cases (63.5%) patients with expiratory phase to reach a plateau, 111 cases (36.5%) patients with no respiratory plateau, these people were aged 〉 65 years; grade Ⅱ 15 cases in lung function (4.9% ), grade Ⅲ 75 cases (24.7%), grade Ⅳ 21 cases (6. 9% ). Patient expiratory time measurement results, 77. 6% (236/304) of patients with expiratory time were 〉 6 s, 36. 8 % (112/ 304) 〉 7 s. Correlation analysis showed, FEV 6 was positively correlated with FVC (r = 0. 357, P = 0. 047). Conclusion FVC is difficult to reach a plateau in aged COPD patients with poor lung function. For patients whose expiratory phase can not reach the plateau and fail to complete FVC effectively, FEV6 can be used as a surrogate marker for FVC.
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