液滴微流控芯片合成单分散PEG水凝胶微球及其粒径调控  

Synthesis of Monodisperse PEG Hydrogel Microball Using a Droplet Microfluidic Chip and Its Size Control

作　　者：刘炳祥[1] 吴婷[1] 王振平[1] 杨晓慧[1] 杜一平[1] 

机构地区：[1]华东理工大学分析测试中心,上海市功能材料化学重点实验室,上海200237

出　　处：《华东理工大学学报（自然科学版）》2014年第2期182-185,共4页Journal of East China University of Science and Technology

基　　金：国家自然科学基金青年基金(21205041);中央高校基本科研业务费(222201314039)

摘　　要：利用液滴微流控技术制备了单分散的微米级聚乙二醇(PEG)水凝胶微球。首先利用流动聚焦型微流控芯片产生单分散的水凝胶微液滴,然后经过紫外光原位引发聚合形成水凝胶微球,系统考察了PEG质量分数、表面活性剂加入量、连续相流速等影响因素,在优化的实验条件下得到了粒径为115μm、单分散性较好的PEG凝胶微球。The monodisperse PEG hydrogel microballs were prepared by droplet microfluidic chip. First,monodisperse microdroplets of PEG hydrogel were successfully prepared in the microfluidic flowfocusing chip.Then,the microdroplets of PEG hydrogel were cured by UV irradiation in situ.Various experimental conditions pertaining to the concentration of PEG hydrogel solution and surfactant,flow rates of continuous phases were investigated.The prepared PEG hydrogel microballs were nearly monosized with a diameter of 115μm under optimal conditions.

关 键 词：微流控芯片 微液滴 PEG水凝胶 粒径调控 

分 类 号：TQ223.162[化学工程—有机化工]