Anti-Nociceptive Effect in Mice of Thillai Flavonoid Rutin  

作　　者：Gurudeeban Selvaraj Satyavani Kaliamurthi Ramanathan Thirungnasambandam Lalitha Vivekanandan Balasubramanian Thangavel 

机构地区：[1]Centre of Advanced Study in Marine Biology, Faculty of Marine Sciences, Annamalai University [2]Nandha College of Pharmacy and Research Institute, Erode, Tamil Nadu, India

出　　处：《Biomedical and Environmental Sciences》2014年第4期295-299,共5页生物医学与环境科学（英文版）

摘　　要：We investigated the anti-nociceptive effect of Excoecorio ogollocho （E.ogollocho） against chemically and thermally induced nociception, Albino mice received a dose of 10, 15, 20, or 25 mg/kg of alkaline chloroform fraction （Alk-CF） of E.ogollocho by oral administration. Compared with controls, AIk-CF decreased the writhing numbers （P〈0.01） in a dose dependent manner. Further we determined that, AIk-CF contained, a potent compared to control, also potent anti-nociceptive agent that acted via opioid receptors and using HPLC, identified this compound as Rutin. Docking simulation demonstrated that Rutin interacted strongly with cyclooxygenase, forming a number of specific hydrogen bonds. In conclusion we have identified peripheral and central anti-nociceptive activities of E.ogollocho that involve opioid receptor, and in which the active compound is Rutin.We investigated the anti-nociceptive effect of Excoecorio ogollocho （E.ogollocho） against chemically and thermally induced nociception, Albino mice received a dose of 10, 15, 20, or 25 mg/kg of alkaline chloroform fraction （Alk-CF） of E.ogollocho by oral administration. Compared with controls, AIk-CF decreased the writhing numbers （P〈0.01） in a dose dependent manner. Further we determined that, AIk-CF contained, a potent compared to control, also potent anti-nociceptive agent that acted via opioid receptors and using HPLC, identified this compound as Rutin. Docking simulation demonstrated that Rutin interacted strongly with cyclooxygenase, forming a number of specific hydrogen bonds. In conclusion we have identified peripheral and central anti-nociceptive activities of E.ogollocho that involve opioid receptor, and in which the active compound is Rutin.

关 键 词：Anti-Nociceptive Effect in Mice of Thillai Flavonoid Rutin CF HIS ORAL RMSD 

分 类 号：R965[医药卫生—药理学]